{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T23:06:13Z","timestamp":1787353573083,"version":"build-2736575974"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T00:00:00Z","timestamp":1309910400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2012,1,28]]},"abstract":"<jats:p>Undernutrition is common among smear-positive pulmonary tuberculosis (PTB+) patients. Micronutrient supplementation may improve treatment outcomes, but it is unclear whether additional energy\u2013protein would be beneficial. The present study aimed to assess the effect of energy\u2013protein supplementation on weight, body composition and handgrip strength against a background of high micronutrient intake during tuberculosis (TB) treatment. A total of 377 PTB+ patients co-infected with HIV were randomly allocated one or six biscuits daily for 60\u00a0d during TB treatment. Weight, arm fat area, arm muscle area and handgrip strength were assessed at baseline and 2 and 5 months. There were no effects on any outcome at 2 months, but energy\u2013protein supplementation was associated with a 1\u00b73 (95\u00a0% CI \u2212\u00a00\u00b71, 2\u00b78)\u00a0kg marginally significant gain in handgrip strength at 5 months. However, after 2 months, energy\u2013protein supplementation led to a weight gain of 1\u00b79 (95\u00a0% CI 0\u00b71, 3\u00b77)\u00a0kg among patients with cluster of differentiation 4 (CD4) counts \u2265\u00a0350\u00a0cells\/\u03bcl, but not among patients with low CD4 counts (\u00a0\u2212\u00a00\u00b72\u00a0kg; 95\u00a0% CI \u2212\u00a01\u00b73, 0\u00b78, <jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a00\u00b703). Similarly, at 5 months, energy\u2013protein supplementation led to a 2\u00b73 (95\u00a0% CI 0\u00b76, 4\u00b71)\u00a0kg higher handgrip strength gain among patients with CD4 counts &lt;\u00a0350\u00a0cells\/\u03bcl, but not in those with high CD4 counts (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a00\u00b704). In conclusion, energy\u2013protein supplementation to PTB+ HIV-co-infected patients had no overall effects on weight and body composition, but was associated with marginally significant gain in handgrip strength. More research is needed to develop an effective supplement, before it is recommended to TB programmes.<\/jats:p>","DOI":"10.1017\/s0007114511002832","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T07:52:21Z","timestamp":1309938741000},"page":"263-271","source":"Crossref","is-referenced-by-count":36,"title":["The effect of energy\u2013protein supplementation on weight, body composition and handgrip strength among pulmonary tuberculosis HIV-co-infected patients: randomised controlled trial in Mwanza, Tanzania"],"prefix":"10.1017","volume":"107","author":[{"given":"George","family":"PrayGod","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyagosya","family":"Range","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Faurholt-Jepsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kidola","family":"Jeremiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Faurholt-Jepsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine G.","family":"Aabye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lotte","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas V.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harleen M. 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