{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:59:28Z","timestamp":1781809168140,"version":"3.54.5"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T00:00:00Z","timestamp":1310688000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2012,2,28]]},"abstract":"<jats:p>We investigated whether the feeding of high H<jats:sub>2<\/jats:sub>-generating dietary fibre and resistant starch (RS) could suppress hepatic ischaemia\u2013reperfusion (IR) injury, which results from oxidative stress, in rats fed a pectin (Pec) or high-amylose maize starch (HAS) diet. Male Sprague\u2013Dawley rats were fed a control (C) diet, with or without Pec (0\u20135\u00a0% Pec) or HAS (0\u201330\u00a0% HAS) supplementation for 7\u00a0d. Portal H<jats:sub>2<\/jats:sub>concentration showed a significant dose-dependent increase with the amount of Pec or HAS supplementation. Plasma alanine and aspartate aminotransferase activities remarkably increased in the C rats (5\u00a0% cellulose) due to IR treatment, while it decreased significantly or showed tendencies to decrease in 5\u00a0% Pec and 20\u00a0% HAS diet-fed rats. The hepatic oxidised glutathione (GSSG):total glutathione ratio increased significantly in IR rats maintained on the C diet compared with sham-operated rats. On the other hand, reduced glutathione (GSH):total glutathione and GSH:GSSG ratios decreased significantly. The GSSG:total glutathione ratio that increased due to IR treatment decreased significantly on HAS and Pec intake, while GSH:total glutathione and GSH:GSSG ratios increased significantly. Hepatic sinusoids of IR rats fed the C diet were occluded, but those of IR rats fed the Pec diet were similar to those in the sham-operated rats. In conclusion, we found that Pec or HAS, which enhance H<jats:sub>2<\/jats:sub>generation in the large intestine, alleviated hepatic IR injury. The present study demonstrates another physiological significance of dietary fibre and RS.<\/jats:p>","DOI":"10.1017\/s0007114511003229","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T13:50:01Z","timestamp":1310737801000},"page":"485-492","source":"Crossref","is-referenced-by-count":39,"title":["Pectin and high-amylose maize starch increase caecal hydrogen production and relieve hepatic ischaemia\u2013reperfusion injury in 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