{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:03:25Z","timestamp":1791227005193,"version":"4.1.0"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T00:00:00Z","timestamp":1310947200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2012,2,28]]},"abstract":"<jats:p>Increased gluconeogenesis (GNG) has been suggested to contribute to protein-induced satiety via modulation of glucose homoeostasis. The objective was to determine GNG and appetite in healthy human subjects after a high-protein<jats:italic>v.<\/jats:italic>a normal-protein diet and to assess whether GNG contributes to protein-induced satiety. A total of twenty-two healthy subjects (ten men and twelve women: age 23 (<jats:sc>sem<\/jats:sc>1) years, BMI 22\u00b71 (<jats:sc>sem<\/jats:sc>0\u00b75)\u00a0kg\/m<jats:sup>2<\/jats:sup>) received an isoenergetic high-protein (30\/0\/70\u00a0% of energy from protein\/carbohydrate\/fat) or normal-protein diet (12\/55\/33\u00a0% of energy from protein\/carbohydrate\/fat) for 1\u00b75\u00a0d in a randomised cross-over design. Appetite ratings were measured using visual analogue scales (VAS); endogenous glucose production and GNG were measured via infusion of [6,6-<jats:sup>2<\/jats:sup>H<jats:sub>2<\/jats:sub>]glucose and ingestion of<jats:sup>2<\/jats:sup>H<jats:sub>2<\/jats:sub>O. Moreover, fasting glucose and \u03b2-hydroxybutyrate concentrations were measured. Glycogen stores were lowered at the start with a glycogen-lowering exercise test. During the high-protein compared with the normal-protein diet, GNG was increased and appetite was suppressed (GNG: 148 (<jats:sc>sem<\/jats:sc>7)<jats:italic>v.<\/jats:italic>133 (<jats:sc>sem<\/jats:sc>6)\u00a0g\/24\u00a0h,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705; and 24\u00a0h area under the curve for hunger: 694 (<jats:sc>sem<\/jats:sc>46)<jats:italic>v.<\/jats:italic>1055 (<jats:sc>sem<\/jats:sc>52)\u00a0m<jats:sc>m<\/jats:sc>VAS\u00a0\u00d7\u00a024\u00a0h,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001; fullness: 806 (<jats:sc>sem<\/jats:sc>59)<jats:italic>v.<\/jats:italic>668 (<jats:sc>sem<\/jats:sc>64)\u00a0mm VAS\u00a0\u00d7\u00a024\u00a0h,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b705; desire to eat: 762 (<jats:sc>sem<\/jats:sc>48)<jats:italic>v.<\/jats:italic>1004 (<jats:sc>sem<\/jats:sc>66)\u00a0mm VAS\u00a0\u00d7\u00a024\u00a0h,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). There was no correlation between appetite ratings and GNG. Glucose concentration was lower (4\u00b709 (<jats:sc>sem<\/jats:sc>0\u00b710)<jats:italic>v.<\/jats:italic>4\u00b789 (<jats:sc>sem<\/jats:sc>0\u00b706)\u00a0mmol\/l,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) and \u03b2-hydroxybutyrate concentration was higher (1349 (<jats:sc>sem<\/jats:sc>139)<jats:italic>v.<\/jats:italic>234 (<jats:sc>sem<\/jats:sc>25)\u00a0\u03bcmol\/l,<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001) after the high-protein compared with the normal-protein diet. In conclusion, after a high-protein diet, GNG was increased and appetite was lower compared with a normal-protein diet; however, these were unrelated to each other. An increased concentration of \u03b2-hydroxybutyrate may have contributed to appetite suppression on the high-protein diet.<\/jats:p>","DOI":"10.1017\/s0007114511003254","type":"journal-article","created":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T14:58:38Z","timestamp":1311001118000},"page":"595-600","source":"Crossref","is-referenced-by-count":37,"title":["Gluconeogenesis and protein-induced satiety"],"prefix":"10.1017","volume":"107","author":[{"given":"Margriet A. B.","family":"Veldhorst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaas R.","family":"Westerterp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margriet S.","family":"Westerterp-Plantenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,7,18]]},"reference":[{"key":"S0007114511003254_ref13","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1152\/jappl.1997.83.6.2064","article-title":"A dual-respiration chamber system with automated calibration","volume":"83","author":"Schoffelen","year":"1997","journal-title":"J Appl Physiol"},{"key":"S0007114511003254_ref7","first-page":"R337","article-title":"Blood glucose patterns and appetite in time-blinded humans: carbohydrate versus fat","volume":"277","author":"Melanson","year":"1999","journal-title":"Am J Physiol"},{"key":"S0007114511003254_ref4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00566.2006"},{"key":"S0007114511003254_ref3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-080508-141056"},{"key":"S0007114511003254_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.863"},{"key":"S0007114511003254_ref11","first-page":"E623","article-title":"Role of glycogen-lowering exercise in the change of fat oxidation in response to a high-fat diet","volume":"273","author":"Schrauwen","year":"1997","journal-title":"Am J Physiol"},{"key":"S0007114511003254_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510002060"},{"key":"S0007114511003254_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581327"},{"key":"S0007114511003254_ref14","first-page":"795","article-title":"On simple formulae for calculating the heat expenditure and the quantities of carbohydrate and fat oxidized in metabolism of men and animals, from gaseous exchange (oxygen intake and carbonic acid output) and urine-N","volume":"6","author":"Brouwer","year":"1957","journal-title":"Acta Physiol Pharmacol Neerl"},{"key":"S0007114511003254_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0306-9877(94)90120-1"},{"key":"S0007114511003254_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(99)00125-2"},{"key":"S0007114511003254_ref20","doi-asserted-by":"publisher","DOI":"10.1126\/science.7193909"},{"key":"S0007114511003254_ref17","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.27834"},{"key":"S0007114511003254_ref23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1093\/ajcn\/87.1.44","article-title":"Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum","volume":"87","author":"Johnstone","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"S0007114511003254_ref18","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/clinchem\/28.4.702","article-title":"Kinetic assay of beta-hydroxybutyrate in plasma with a COBAS-BIO centrifugal analyzer","volume":"28","author":"Moore","year":"1982","journal-title":"Clin Chem"},{"key":"S0007114511003254_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32831b9e01"},{"key":"S0007114511003254_ref12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.4.12.370"},{"key":"S0007114511003254_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0149-7634(95)00043-E"},{"key":"S0007114511003254_ref16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118803"},{"key":"S0007114511003254_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2008.01.003"},{"key":"S0007114511003254_ref9","doi-asserted-by":"publisher","DOI":"10.1089\/154041903322716688"},{"key":"S0007114511003254_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(83)90070-7"},{"key":"S0007114511003254_ref15","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600782"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114511003254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T10:33:31Z","timestamp":1592735611000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114511003254\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,18]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,2,28]]}},"alternative-id":["S0007114511003254"],"URL":"https:\/\/doi.org\/10.1017\/s0007114511003254","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,18]]}}}