{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:25:37Z","timestamp":1760549137921},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T00:00:00Z","timestamp":1311638400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2012,3,14]]},"abstract":"<jats:p>Within a neonatal vitamin A supplementation (VAS) trial, we investigated the effect of VAS on TNF-\u03b1, IL-10, IL-5 and IL-13 production after lipopolysaccharide, purified protein derivative (PPD) of <jats:italic>Mycobacterium tuberculosis<\/jats:italic> and phytohaemagglutinin stimulation using a whole blood culture protocol. We found that VAS recipients had lower unstimulated TNF-\u03b1 concentrations than placebo recipients. In the present paper, we investigated whether the SNP <jats:italic>TNF-\u03b1<\/jats:italic> \u2212\u00a0308, <jats:italic>TNF-\u03b1<\/jats:italic> \u2212\u00a0238, <jats:italic>IL-10<\/jats:italic> \u2212\u00a0592, <jats:italic>IL-10<\/jats:italic> \u2212\u00a01082 and toll-like receptor 4 (<jats:italic>TLR4<\/jats:italic>)+896 modified the effect of VAS on cytokine production. DNA and cytokine concentrations were available from 291 children. We found a significant interaction between <jats:italic>TNF-\u03b1<\/jats:italic> \u2212\u00a0308 genotype and VAS for the unstimulated TNF-\u03b1 production (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a00\u00b704); among G homozygotes, TNF-\u03b1 concentrations were significantly lower after VAS compared with placebo, whereas for A carriers, VAS did not appear to have any effect. For <jats:italic>TNF-\u03b1<\/jats:italic> \u2212\u00a0238, there was a tendency towards an increase in PPD-stimulated TNF-\u03b1 production after VAS for the G homozygotes, but the opposite tendency for A allele carriers (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>\u00a0=\u00a00\u00b707). Stratification by sex revealed a significant VAS\u2013genotype interaction for boys for <jats:italic>TNF-\u03b1<\/jats:italic> \u2212\u00a0238. There was a borderline-significant three-way interaction (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b705) between sex, VAS and <jats:italic>TLR4<\/jats:italic>+896 genotype. Although the present study had very limited representation of the genetic variation with potential for modification of the response to VAS, it adds to the efforts of untangling the diverse effects and impact of VAS.<\/jats:p>","DOI":"10.1017\/s0007114511003515","type":"journal-article","created":{"date-parts":[[2011,7,26]],"date-time":"2011-07-26T14:29:48Z","timestamp":1311690588000},"page":"615-620","source":"Crossref","is-referenced-by-count":6,"title":["SNP may modify the effect of vitamin A supplementation at birth on cytokine production in a whole blood culture assay"],"prefix":"10.1017","volume":"107","author":[{"given":"Mathias Jul","family":"J\u00f8rgensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ane B\u00e6rent","family":"Fisker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mogens H.","family":"Claesson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine Stabell","family":"Benn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,7,26]]},"reference":[{"key":"S0007114511003515_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2008.11.006"},{"key":"S0007114511003515_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2370.1997.tb00001.x"},{"key":"S0007114511003515_ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-3-21"},{"key":"S0007114511003515_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg208"},{"key":"S0007114511003515_ref1","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19970046"},{"key":"S0007114511003515_ref10","doi-asserted-by":"publisher","DOI":"10.1053\/jlts.2002.50014"},{"key":"S0007114511003515_ref12","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.112268"},{"key":"S0007114511003515_ref2","volume-title":"Effectiveness of Vitamin A Supplementation in the Control of Young Child Morbidity and Mortality in Developing Countries","author":"Beaton","year":"1993"},{"key":"S0007114511003515_ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39542.509444.AE"},{"key":"S0007114511003515_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03612.x"},{"key":"S0007114511003515_ref8","first-page":"62","article-title":"The promoter polymorphism of the interleukin-6 gene regulates interleukin-6 production in neonates but not in adults","volume":"12","author":"Kilpinen","year":"2001","journal-title":"Eur Cytokine Netw"},{"key":"S0007114511003515_ref6","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0103026"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114511003515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T23:57:14Z","timestamp":1556236634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114511003515\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,26]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,3,14]]}},"alternative-id":["S0007114511003515"],"URL":"https:\/\/doi.org\/10.1017\/s0007114511003515","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,26]]}}}