{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:03:17Z","timestamp":1793725397489,"version":"4.6.1"},"reference-count":48,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T00:00:00Z","timestamp":1320796800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2012,8,14]]},"abstract":"<jats:p>We investigated the effects of prolonged treatment of diabetic rats with curcumin-supplemented yoghurt on the physiological and biochemical changes associated with diabetes mellitus. An established metabolic cage model was used to assess these changes in three groups of streptozotocin-diabetic rats which had been administered, by gavage, curcumin blended into yoghurt in the doses of 30, 60 and 90\u00a0mg\/kg body weight (BW) per d (groups DC<jats:sub>30<\/jats:sub>, DC<jats:sub>60<\/jats:sub>, DC<jats:sub>90<\/jats:sub>) for 31\u00a0d. One group of non-diabetic rats was also treated with 90\u00a0mg\/kg BW per d curcumin (NDC90). Three control groups of diabetic animals received water (DW), yoghurt (DY) and insulin at 27\u00b778\u00a0\u03bcmol\/d by subcutaneous injection (DI). Also, two groups of non-diabetic animals received water (NDW) and yoghurt (NDY). Groups DI and DC90 exhibited significant falls, relative to DW and DY, in food and water intake, urine volume, glycaemia, urinary urea and glucose, proteinuria, serum TAG and activities of aspartate and alanine aminotransferases, and higher hepatic glycogen and BW. These improvements were greater in DI than in DC90. No difference was observed in the serum levels of total cholesterol or HDL-cholesterol, or in the masses of adipose and muscular tissues, between DC90 and DW or DY. Moreover, the improvements in curcumin-treated rats, relative to DW and DY, were significant and dose-dependent. The NDC90 group also showed no difference from the NDW or NDY groups, in any of the markers for diabetes. In conclusion, curcumin mixed into yoghurt at the highest dose tested exhibited anti-diabetic activity, improving significantly most of the markers assessed in this study.<\/jats:p>","DOI":"10.1017\/s0007114511005769","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T12:14:23Z","timestamp":1320840863000},"page":"440-448","source":"Crossref","is-referenced-by-count":52,"title":["Curcumin-supplemented yoghurt improves physiological and biochemical markers of experimental diabetes"],"prefix":"10.1017","volume":"108","author":[{"given":"V\u00e2nia O.","family":"Gutierres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara M.","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata P.","family":"Assis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina C.","family":"Vendramini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Pepato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iguatemy L.","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,11,9]]},"reference":[{"key":"S0007114511005769_ref12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04-1304"},{"key":"S0007114511005769_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.07.078"},{"key":"S0007114511005769_ref4","first-page":"192","article-title":"Effects of yoghurt supplementation on the growth of preschool children in Beijing suburbs","volume":"18","author":"He","year":"2005","journal-title":"Biomed Environ Sci"},{"key":"S0007114511005769_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2009.11.009"},{"key":"S0007114511005769_ref44","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/01.mol.0000226115.97436.c0","article-title":"Diabetic dyslipidaemia","volume":"17","author":"Martin","year":"2006","journal-title":"Curr Opin Lipidol"},{"key":"S0007114511005769_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2010.05.073"},{"key":"S0007114511005769_ref42","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.1.139"},{"key":"S0007114511005769_ref7","doi-asserted-by":"publisher","DOI":"10.1021\/jf0483873"},{"key":"S0007114511005769_ref40","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013106527829"},{"key":"S0007114511005769_ref39","doi-asserted-by":"publisher","DOI":"10.1300\/J044v10n01_09"},{"key":"S0007114511005769_ref37","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330306"},{"key":"S0007114511005769_ref34","doi-asserted-by":"publisher","DOI":"10.1042\/BA20030034"},{"key":"S0007114511005769_ref32","first-page":"410","article-title":"Two methods for the determination of glycogen in liver","volume":"57","author":"Vies","year":"1953","journal-title":"Pharmacol Res"},{"key":"S0007114511005769_ref28","first-page":"226","article-title":"Development of homogeneous assay for HDL-C in serum","volume":"50","author":"Sugiuchi","year":"2002","journal-title":"Risho Byori"},{"key":"S0007114511005769_ref27","first-page":"903","volume-title":"Tietz Textbook of Clinical Chemistry and Molecular Diagnostics","author":"Rifai","year":"2006"},{"key":"S0007114511005769_ref26","first-page":"731","article-title":"IFCC methods for the measurement of catalytic concentraction of enzymes. Part 5. IFCC method for alkaline phosphatase (orthphosphoric-monoester phosphohydrolase, alkaline optimum, EC 3.1.3.1)","volume":"21","author":"Tietz","year":"1983","journal-title":"J Clin Chem Clin Biochem"},{"key":"S0007114511005769_ref24","doi-asserted-by":"publisher","DOI":"10.1177\/000456326900600108"},{"key":"S0007114511005769_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2006.09.025"},{"key":"S0007114511005769_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.08.016"},{"key":"S0007114511005769_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.appet.2008.05.060"},{"key":"S0007114511005769_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"S0007114511005769_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700184"},{"key":"S0007114511005769_ref47","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2007.09.013"},{"key":"S0007114511005769_ref38","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1515\/JBCPP.2005.16.4.257","article-title":"Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes in streptozotocin induced diabetic rats","volume":"4","author":"Pari","year":"2005","journal-title":"J Basic Clin Physiol Pharmacol"},{"key":"S0007114511005769_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2008.09.009"},{"key":"S0007114511005769_ref19","doi-asserted-by":"publisher","DOI":"10.1021\/mp700113r"},{"key":"S0007114511005769_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2007.12.004"},{"key":"S0007114511005769_ref25","doi-asserted-by":"publisher","DOI":"10.3109\/00365517409082499"},{"key":"S0007114511005769_ref1","first-page":"837","volume-title":"Tietz Textbook of Clinical Chemistry and Molecular Diagnostics","author":"Sacks","year":"2006"},{"key":"S0007114511005769_ref8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3923\/ijzr.2010.266.276","article-title":"Antioxidant effect of curcumin extracts in induced diabetic wister rats","volume":"6","author":"Hussein","year":"2010","journal-title":"Int J Zool Res"},{"key":"S0007114511005769_ref14","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006821828706"},{"key":"S0007114511005769_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2006.04468.x"},{"key":"S0007114511005769_ref30","first-page":"449","volume-title":"Methods of Enzymatic Analysis","author":"Bergmeyer","year":"1985"},{"key":"S0007114511005769_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4514.2006.00091.x"},{"key":"S0007114511005769_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2009.02.019"},{"key":"S0007114511005769_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/131.11.2932"},{"key":"S0007114511005769_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.04.001"},{"key":"S0007114511005769_ref17","first-page":"73","article-title":"Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guineapigs and monkeys","volume":"18","author":"Shankar","year":"1980","journal-title":"Indian J Exp Biol"},{"key":"S0007114511005769_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509993667"},{"key":"S0007114511005769_ref9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006819605211"},{"key":"S0007114511005769_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-6-10"},{"key":"S0007114511005769_ref48","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF01076459","article-title":"Influence of dietary curcumin and cholesterol on the progression of experimentally induced diabetes in albino rat","volume":"1","author":"Babu","year":"1995","journal-title":"Mol Cell Biochem"},{"key":"S0007114511005769_ref45","first-page":"273","article-title":"Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers","volume":"36","author":"Soni","year":"1992","journal-title":"Indian J Physiol Pharmacol"},{"key":"S0007114511005769_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2007.07.003"},{"key":"S0007114511005769_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2009.10.007"},{"key":"S0007114511005769_ref23","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957450"},{"key":"S0007114511005769_ref31","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/clinchem\/8.3.215","article-title":"An o-toluidine method for body fluid glucose determination","volume":"8","author":"Dubowski","year":"1962","journal-title":"Clin Chem"},{"key":"S0007114511005769_ref33","doi-asserted-by":"publisher","DOI":"10.1021\/jf030417z"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114511005769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T15:22:43Z","timestamp":1713108163000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114511005769\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,9]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,8,14]]}},"alternative-id":["S0007114511005769"],"URL":"https:\/\/doi.org\/10.1017\/s0007114511005769","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,9]]}}}