{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:19:24Z","timestamp":1792030764170,"version":"4.4.0"},"reference-count":53,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T00:00:00Z","timestamp":1323907200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2012,9,28]]},"abstract":"<jats:p>Several studies have shown that blood vitamin levels are lower in alcoholic patients than in control subjects. Acute ethanol exposure enhances the release of vitamins from liver cells<jats:italic>in vitro.<\/jats:italic>The aim of the present study is to confirm the effects of ethanol consumption on vitamin contents<jats:italic>in vivo.<\/jats:italic>We compared the contents of B-group vitamins in the liver, blood and urine between ethanol-fed and control rats fed a diet containing a sufficient- and low-vitamin mixture. The experimental rats were fed a 15\u00a0% ethanol solution freely for 28\u00a0d, and then 24\u00a0h urine samples were collected, after which the animals were killed. The B-group vitamin contents in the liver, blood and urine were measured. No differences in liver, blood and urine contents were observed between the control and ethanol-fed rats fed a diet containing a sufficient-vitamin mixture. On the contrary, in rats fed a diet containing a low-vitamin mixture, consumption of ethanol caused a decrease in the contents of vitamins B<jats:sub>1<\/jats:sub>, B<jats:sub>2<\/jats:sub>and pantothenic acid in the liver; however, the contents of the other vitamins did not decrease. In the blood, the contents of vitamins B<jats:sub>1<\/jats:sub>, B<jats:sub>2<\/jats:sub>, B<jats:sub>6<\/jats:sub>and pantothenic acid were lower in the ethanol-fed rats than in the controls. Urinary excretion of the B-group vitamins, except for niacin, was lower in the ethanol-fed rats. These results show that ethanol consumption affects the absorption, distribution and excretion of each of the vitamins in rats fed a diet containing a low-vitamin mixture.<\/jats:p>","DOI":"10.1017\/s0007114511006192","type":"journal-article","created":{"date-parts":[[2011,12,15]],"date-time":"2011-12-15T09:46:43Z","timestamp":1323942403000},"page":"1034-1041","source":"Crossref","is-referenced-by-count":14,"title":["Effects of ethanol consumption on the B-group vitamin contents of liver, blood and urine in rats"],"prefix":"10.1017","volume":"108","author":[{"given":"Aiko","family":"Miyazaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsue","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsutomu","family":"Fukuwatari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,12,15]]},"reference":[{"key":"S0007114511006192_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/16.4.339"},{"key":"S0007114511006192_ref43","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.56.1104"},{"key":"S0007114511006192_ref20","first-page":"1005","article-title":"Pantothenic acid, fatty liver and alcoholism","volume":"39","author":"Leevy","year":"1960","journal-title":"J Clin Invest"},{"key":"S0007114511006192_ref30","first-page":"187","article-title":"A simple method for micro-determination of flavin in human serum and whole blood by high-performance liquid chromatography","volume":"4","author":"Ohkawa","year":"1982","journal-title":"Biochem Int"},{"key":"S0007114511006192_ref6","first-page":"166","article-title":"Vitamins and alcoholism. 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