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Expression levels of these proteins and hepatic hepcidin and serum Fe levels were determined in inflamed mice. In acutely inflamed mice, significantly increased expression of ferritin was the earliest change observed, followed by decreased divalent metal transporter 1 expression in the duodenum and increased hepcidin expression in the liver. Ferroportin expression increased subsequently, despite high levels of hepcidin. Hypoferraemia, which developed at early time periods studied, was followed by increased serum Fe levels at later points. The present results thus show that acute inflammation induced several changes in the expression of proteins involved in duodenal Fe absorption, contributing to the development of hypoferraemia. Resolution of inflammation caused attenuation of many of these effects. Effects in chronically inflamed mice were less consistent. The present results also suggest that inflammation-induced increases in ferritin appeared to override the effects of hepcidin on the expression levels of ferroportin in enterocytes.<\/jats:p>","DOI":"10.1017\/s0007114512000189","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T12:02:26Z","timestamp":1330084946000},"page":"1994-2001","source":"Crossref","is-referenced-by-count":5,"title":["Effects of acute and chronic inflammation on proteins involved in duodenal iron absorption in mice: a time-course study"],"prefix":"10.1017","volume":"108","author":[{"given":"Abitha","family":"Sukumaran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe","family":"Varghese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesintha","family":"Tamilselvan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Visalakshi","family":"Jeyaseelan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thenmozhi","family":"Mani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert James","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew Tristan","family":"McKie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"S0007114512000189_ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0542-3"},{"key":"S0007114512000189_ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006618"},{"key":"S0007114512000189_ref3","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21441"},{"key":"S0007114512000189_ref4","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3364"},{"key":"S0007114512000189_ref34","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.3.340"},{"key":"S0007114512000189_ref21","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s00204-003-0525-0","article-title":"Free radical generating agents lead to the rapid progression of benign skin tumors to carcinoma in iron-overloaded mice","volume":"78","author":"Bhasin","year":"2004","journal-title":"Arch Toxicol"},{"key":"S0007114512000189_ref19","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195651"},{"key":"S0007114512000189_ref15","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M201485200"},{"key":"S0007114512000189_ref40","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2.2.110"},{"key":"S0007114512000189_ref37","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.24033"},{"key":"S0007114512000189_ref10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1176639"},{"key":"S0007114512000189_ref29","doi-asserted-by":"publisher","DOI":"10.1038\/nature07472"},{"key":"S0007114512000189_ref17","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008923200"},{"key":"S0007114512000189_ref12","doi-asserted-by":"crossref","first-page":"12638","DOI":"10.1016\/S0021-9258(18)37801-3","article-title":"The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene","volume":"263","author":"Torti","year":"1988","journal-title":"J Biol Chem"},{"key":"S0007114512000189_ref30","doi-asserted-by":"crossref","first-page":"14572","DOI":"10.1016\/S0021-9258(18)77341-9","article-title":"Translational control during the acute phase response. 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