{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:39:43Z","timestamp":1768250383019,"version":"3.49.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T00:00:00Z","timestamp":1330041600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2012,12,14]]},"abstract":"<jats:p>Low maternal vitamin D levels have been associated with adverse pregnancy outcome. A recent study has suggested that low maternal vitamin D levels at the time of delivery are also associated with an almost fourfold increase in caesarean section risk. The aim of the present study was to investigate whether there is a difference in maternal serum 25-hydroxyvitamin D (25(OH)D) levels at 11\u201313 weeks' gestation according to the mode of delivery. Maternal serum 25(OH)D levels were measured at 11\u201313 weeks' gestation in 995 singleton pregnancies resulting in the birth of phenotypically normal neonates at term. The measured 25(OH)D levels were adjusted for maternal age, BMI, racial origin, smoking, method of conception and season of blood testing, and the adjusted levels (multiple of the median; MoM) were compared between those who subsequently delivered vaginally and those that delivered by caesarean section. Delivery was vaginal in 79\u00b76\u00a0% of cases, by emergency caesarean section in 11\u00b76\u00a0% and by elective caesarean section in 8\u00b78\u00a0%. The median 25(OH)D level in our population was 46\u00b782 (interquartile range (IQR) 27\u00b775\u201370\u00b713)\u00a0nmol\/l. The adjusted maternal median 25(OH)D levels in the emergency and elective caesarean section groups (0\u00b799, IQR 0\u00b771\u20131\u00b746 MoM and 0\u00b796, IQR 0\u00b773\u20131\u00b727 MoM, respectively) were not significantly different from the vaginal delivery group (0\u00b799, IQR 0\u00b771\u20131\u00b733 MoM;<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b753 and<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b781, respectively). First-trimester maternal serum 25(OH)D levels are similar between women who subsequently have a vaginal delivery and those who deliver by elective or emergency caesarean section.<\/jats:p>","DOI":"10.1017\/s0007114512000207","type":"journal-article","created":{"date-parts":[[2012,2,24]],"date-time":"2012-02-24T12:01:53Z","timestamp":1330084913000},"page":"1972-1975","source":"Crossref","is-referenced-by-count":25,"title":["First-trimester maternal serum vitamin D and mode of delivery"],"prefix":"10.1017","volume":"108","author":[{"given":"Makrina D.","family":"Savvidou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahlatse","family":"Makgoba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro T.","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjit","family":"Akolekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kypros H.","family":"Nicolaides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,2,24]]},"reference":[{"key":"S0007114512000207_ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.3.752"},{"key":"S0007114512000207_ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0718"},{"key":"S0007114512000207_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2520"},{"key":"S0007114512000207_ref5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0003753"},{"key":"S0007114512000207_ref6","doi-asserted-by":"crossref","first-page":"8882","DOI":"10.1016\/S0021-9258(17)39433-4","article-title":"Identification of 1,25-dihydroxyvitamin D3 receptors and activities in muscle","volume":"260","author":"Simpson","year":"1985","journal-title":"J Biol Chem"},{"key":"S0007114512000207_ref4","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.119636"},{"key":"S0007114512000207_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(92)90127-F"},{"key":"S0007114512000207_ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1217"},{"key":"S0007114512000207_ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000324340"},{"key":"S0007114512000207_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5331"},{"key":"S0007114512000207_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/88.2.507S"},{"key":"S0007114512000207_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.12.001"},{"key":"S0007114512000207_ref7","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-7-4-434"},{"key":"S0007114512000207_ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0298"},{"key":"S0007114512000207_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(97)00255-8"},{"key":"S0007114512000207_ref1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.706127"},{"key":"S0007114512000207_ref17","doi-asserted-by":"publisher","DOI":"10.1080\/j.1600-0412.1998.770309.x"},{"key":"S0007114512000207_ref13","doi-asserted-by":"publisher","DOI":"10.1080\/j.1600-0412.2000.079003174.x"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114512000207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T20:38:31Z","timestamp":1640896711000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114512000207\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,24]]},"references-count":18,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,12,14]]}},"alternative-id":["S0007114512000207"],"URL":"https:\/\/doi.org\/10.1017\/s0007114512000207","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,24]]}}}