{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:46:29Z","timestamp":1791308789705,"version":"4.3.1"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T00:00:00Z","timestamp":1333411200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2013,1,14]]},"abstract":"<jats:p>The digestive function of low birth weight (LBW) pigs post-weaning has been poorly studied. Therefore, newborns from eleven hyperprolific sows were weighed, weaned at 27\u00b72\u00a0d and fed a starter diet until sampling. Sampling was done between 18 and 28\u00a0d post-weaning. An LBW piglet (<jats:italic>n<\/jats:italic>19) was defined as a piglet having a birth weight less than 1\u00a0kg and less than the lower quartile of litter birth weights. Normal birth weight (NBW) piglets (<jats:italic>n<\/jats:italic>13) were having a birth weight close to the mean litter birth weight. For each piglet, eighty-eight variables were determined. Data were analysed with linear models with type of piglet and litter as predictors. A principal component analysis was performed to determine the most important discriminating variables. In the LBW pig, the development of the digestive tract post-weaning was delayed: lower small-intestinal weight:length ratio due to a thinner tela submucosa and tunica muscularis and a higher secretory capacity, both in the distal jejunum. These observations might be a consequence of lower circulating insulin-like growth factor-1 (IGF-1) concentrations (126 (<jats:sc>se<\/jats:sc>10\u00b70)<jats:italic>v<\/jats:italic>. 158 (<jats:sc>se<\/jats:sc>12\u00b70)\u00a0ng\/ml for LBW and NBW, respectively) and a lower density of IGF-1 receptors in the proximal small intestine. Additionally, the plasma antioxidant capacity was lower for the LBW pig. Taken together, in the LBW piglet, the normal gut maturation post-weaning was retarded and this did not seem to be related to the weaning transition as such.<\/jats:p>","DOI":"10.1017\/s0007114512000670","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T13:27:25Z","timestamp":1333459645000},"page":"65-75","source":"Crossref","is-referenced-by-count":84,"title":["Maturation of digestive function is retarded and plasma antioxidant capacity lowered in fully weaned low birth weight piglets"],"prefix":"10.1017","volume":"109","author":[{"given":"Joris","family":"Michiels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maartje","family":"De 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