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A total of fifty pancreatic cancer patients were analysed for skeletal muscle and visceral adipose tissue (VAT) changes using computed tomography (CT) scans. These changes were related to physical characteristics, secondary disease states and treatment parameters. Overall, patients lost 1\u00b772 (<jats:sc>sd<\/jats:sc> 3\u00b729)\u00a0kg of muscle and 1\u00b704 (<jats:sc>sd<\/jats:sc> 1\u00b708)\u00a0kg of VAT during the disease trajectory (413 (<jats:sc>sd<\/jats:sc> 213)\u00a0d). After sorting patients into tertiles by rate of VAT and muscle loss, patients losing VAT at &gt;\u00a0\u2212\u00a00\u00b740\u00a0kg\/100\u00a0d had poorer survival outcomes compared with patients with &lt;\u00a0\u2212\u00a00\u00b710\u00a0kg\/100\u00a0d of VAT loss (<jats:italic>P<\/jats:italic>=\u00a00\u00b7020). Patients presenting with diabetes at diagnosis demonstrated significantly more and accelerated VAT loss compared with non-diabetic patients. In contrast, patients who were anaemic at the first CT scan lost significantly more muscle tissue and at accelerated rates compared with non-anaemic patients. Accelerated rates of VAT loss are associated with reduced survival. Identifying associated features of cachexia, such as diabetes and anaemia, is essential for the early detection of cachexia and may facilitate the attenuation of complications associated with cachexia.<\/jats:p>","DOI":"10.1017\/s0007114512001067","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T10:42:54Z","timestamp":1353494574000},"page":"302-312","source":"Crossref","is-referenced-by-count":129,"title":["Accelerated muscle and adipose tissue loss may predict survival in pancreatic cancer patients: the relationship with diabetes and anaemia"],"prefix":"10.1017","volume":"109","author":[{"given":"Katie M. 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