{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:34:34Z","timestamp":1791221674763,"version":"4.1.0"},"reference-count":93,"publisher":"Cambridge University Press (CUP)","issue":"S2","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>Studies examining the health benefits of high-protein diets typical of most affluent and many developing countries are not consistent. Prospective epidemiological studies relating dietary protein to clinical and metabolic endpoints suggest increased weight gain and increased risk of diabetes amongst those with a high protein intake and an increased risk of cancer with high intakes of red meat, but lower blood pressure and possibly a reduced risk of heart disease with higher protein intakes. The potential for high-protein diets to confer greater benefit than other diets has been examined using <jats:italic>ad libitum<\/jats:italic> and energy restricted diets. Of greatest interest have been the comparisons between high-protein and high-carbohydrate diets. Many trials have reported greater weight loss especially in the context of <jats:italic>ad libitum<\/jats:italic> diets over the short-to medium-term, sparing of lean body mass, lowering of triglyceride levels, improved HDL: total cholesterol ratio and improved glycaemic control. Limited data regarding insulin sensitivity are less consistent. A major difficulty in interpreting the results of these studies is that carbohydrate quality has not been taken into account. Furthermore, longer term comparisons of weight reducing diets differing in macronutrient composition have reported similar outcomes, suggesting that compliance is a more important consideration. Nevertheless dietary patterns with high-protein intakes are appropriate for weight reduction and weight maintenance and may be useful for those who have high triglyceride levels and other features of the metabolic syndrome.<\/jats:p>","DOI":"10.1017\/s0007114512002437","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T06:20:00Z","timestamp":1351578000000},"page":"S130-S138","source":"Crossref","is-referenced-by-count":35,"title":["The role of high-protein diets in body weight management and health"],"prefix":"10.1017","volume":"108","author":[{"given":"Lisa","family":"Te Morenga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"key":"S0007114512002437_ref78","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508003061"},{"key":"S0007114512002437_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22170"},{"key":"S0007114512002437_ref57","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.1.57"},{"key":"S0007114512002437_ref68","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28713"},{"key":"S0007114512002437_ref37","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/75.1.11"},{"key":"S0007114512002437_ref77","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-008-0767-y"},{"key":"S0007114512002437_ref14","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28060"},{"key":"S0007114512002437_ref42","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.531"},{"key":"S0007114512002437_ref64","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.5.1571S"},{"key":"S0007114512002437_ref38","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602940"},{"key":"S0007114512002437_ref52","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051521"},{"key":"S0007114512002437_ref80","first-page":"743","article-title":"Effects of a high-protein meal (meat) and a high-carbohydrate meal (vegetarian) on satiety measured by automated computerized monitoring of subsequent food intake, motivation to eat and food preferences","volume":"14","author":"Barkeling","year":"1990","journal-title":"Int J Obes"},{"key":"S0007114512002437_ref50","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2005.01.009"},{"key":"S0007114512002437_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyg151"},{"key":"S0007114512002437_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.1.31"},{"key":"S0007114512002437_ref22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803075"},{"key":"S0007114512002437_ref18","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800867"},{"key":"S0007114512002437_ref56","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(80)90166-3"},{"key":"S0007114512002437_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.2.260"},{"key":"S0007114512002437_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/0884533610385702"},{"key":"S0007114512002437_ref75","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28713"},{"key":"S0007114512002437_ref82","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600782"},{"key":"S0007114512002437_ref79","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/138.4.698"},{"key":"S0007114512002437_ref67","volume-title":"Food and Nutrition Guidelines for Healthy Adults: A background paper. no. 0-478-25839-9","year":"2003"},{"key":"S0007114512002437_ref74","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803305"},{"key":"S0007114512002437_ref83","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.1.89"},{"key":"S0007114512002437_ref7","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1321"},{"key":"S0007114512002437_ref5","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.9.2108"},{"key":"S0007114512002437_ref46","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.7.539"},{"key":"S0007114512002437_ref61","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.1.242S"},{"key":"S0007114512002437_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.915165"},{"key":"S0007114512002437_ref63","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/78.4.734"},{"key":"S0007114512002437_ref43","doi-asserted-by":"publisher","DOI":"10.3945\/jn.108.099440"},{"key":"S0007114512002437_ref54","doi-asserted-by":"publisher","DOI":"10.1089\/dia.2006.8.338"},{"key":"S0007114512002437_ref35","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1511-7"},{"key":"S0007114512002437_ref36","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801064"},{"key":"S0007114512002437_ref85","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2008.01.003"},{"key":"S0007114512002437_ref31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802617"},{"key":"S0007114512002437_ref91","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-002-0212-0"},{"key":"S0007114512002437_ref90","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.2.405"},{"key":"S0007114512002437_ref33","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.1.43"},{"key":"S0007114512002437_ref93","first-page":"CR266","article-title":"Evaluation of the antihypertensive effect of L-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring","volume":"16","author":"Ast","year":"2010","journal-title":"Med Sci Monit"},{"key":"S0007114512002437_ref39","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-10-40"},{"key":"S0007114512002437_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.3.586"},{"key":"S0007114512002437_ref72","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.6.1335"},{"key":"S0007114512002437_ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012102"},{"key":"S0007114512002437_ref6","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507853360"},{"key":"S0007114512002437_ref45","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.8.1944"},{"key":"S0007114512002437_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.166.3.285"},{"key":"S0007114512002437_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2008.00518.x"},{"key":"S0007114512002437_ref8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2081"},{"key":"S0007114512002437_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi038"},{"key":"S0007114512002437_ref19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022637"},{"key":"S0007114512002437_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802767"},{"key":"S0007114512002437_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1603-4"},{"key":"S0007114512002437_ref23","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2008.278"},{"key":"S0007114512002437_ref24","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.445"},{"key":"S0007114512002437_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.2.411"},{"key":"S0007114512002437_ref28","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.6.1298"},{"key":"S0007114512002437_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.5.1025"},{"key":"S0007114512002437_ref30","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-5-30"},{"key":"S0007114512002437_ref32","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.1.23"},{"key":"S0007114512002437_ref34","doi-asserted-by":"publisher","DOI":"10.1001\/jama.297.9.969"},{"key":"S0007114512002437_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(94)90005-1"},{"key":"S0007114512002437_ref41","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/82.1.41"},{"key":"S0007114512002437_ref44","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021262"},{"key":"S0007114512002437_ref47","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199602153340707"},{"key":"S0007114512002437_ref48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2006.tb00227.x"},{"key":"S0007114512002437_ref51","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.25.050304.092545"},{"key":"S0007114512002437_ref53","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2010.163"},{"key":"S0007114512002437_ref58","first-page":"140","article-title":"Replacement of carbohydrate by protein in a conventional-fat diet reduces cholesterol and triglyceride concentrations in healthy normolipidemic subjects","volume":"22","author":"Wolfe","year":"1999","journal-title":"Clin Invest Med"},{"key":"S0007114512002437_ref60","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.19.2455"},{"key":"S0007114512002437_ref62","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.4.780"},{"key":"S0007114512002437_ref84","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.1.91"},{"key":"S0007114512002437_ref65","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.80.5.1320"},{"key":"S0007114512002437_ref66","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2002407"},{"key":"S0007114512002437_ref69","first-page":"145","article-title":"Predictors of weight change over two years among a population of working adults: the Healthy Worker Project","volume":"18","author":"French","year":"1994","journal-title":"Int J Obes Relat Metab Disord"},{"key":"S0007114512002437_ref71","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.87.5.747"},{"key":"S0007114512002437_ref73","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.2.362"},{"key":"S0007114512002437_ref76","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-080508-141056"},{"key":"S0007114512002437_ref86","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.5.1135"},{"key":"S0007114512002437_ref87","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508131774"},{"key":"S0007114512002437_ref88","doi-asserted-by":"publisher","DOI":"10.1159\/000103323"},{"key":"S0007114512002437_ref89","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/136.1.319S"},{"key":"S0007114512002437_ref70","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0800490"},{"key":"S0007114512002437_ref92","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(02)00413-8"},{"key":"S0007114512002437_ref13","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29626"},{"key":"S0007114512002437_ref59","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.94.7.1629"},{"key":"S0007114512002437_ref81","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-1856"},{"key":"S0007114512002437_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn.70.2.221"},{"key":"S0007114512002437_ref10","volume-title":"Food, Nutrition, and Physical Activity, and the Prevention of Cancer: A Global Perspective","year":"2007"},{"key":"S0007114512002437_ref49","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.3.425"},{"key":"S0007114512002437_ref55","first-page":"E212","article-title":"Effect of dietary protein on in vivo insulin action and liver glycogen repletion","volume":"257","author":"Rossetti","year":"1989","journal-title":"Am J Physiol"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114512002437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T02:22:53Z","timestamp":1554949373000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114512002437\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":93,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0007114512002437"],"URL":"https:\/\/doi.org\/10.1017\/s0007114512002437","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}