{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:28:47Z","timestamp":1790209727042,"version":"4.1.0"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T00:00:00Z","timestamp":1351814400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2013,6,28]]},"abstract":"<jats:p>The growth hormone (GH)\u2013insulin-like growth factor-1 (IGF-1) axis is dramatically altered in patients with anorexia nervosa (AN). The aim of the present study was to investigate whether GH and IGF-1 could be predictors of outcome in patients with a restrictive form of AN. Blood levels of GH, IGF-1, adipocytokines, ghrelin, insulin, glucose, and sex and thyroid hormones were measured in eleven women inpatients with AN and in ten healthy women controls. Three stages were compared during refeeding: admission (T0), when BMI reached 16\u00a0kg\/m<jats:sup>2<\/jats:sup> (T1) and at discharge when BMI reached 17\u00b75\u00a0kg\/m<jats:sup>2<\/jats:sup> (T2). Clinical status was assessed 6 months after discharge from hospital (T3), and remission was defined by the maintenance of a BMI \u2265\u00a017\u00b75\u00a0kg\/m<jats:sup>2<\/jats:sup>. AN patients in remission (AN-R; <jats:italic>n<\/jats:italic> 6) had significantly higher GH levels at admission than those who relapsed (AN-NR; <jats:italic>n<\/jats:italic> 5) (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705). During refeeding (\u0394\u00a0=\u00a0T2\u00a0\u2212\u00a0T0), the AN-R group differed from the AN-NR group only by both GH level decrease (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705) and BMI increase (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705). In multiple regression analysis, \u0394GH was associated negatively and significantly and \u0394leptin and \u0394body fat mass levels were associated positively and significantly with BMI at T3 and explained 88\u00a0% of its variability (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup> 0\u00b788, <jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705). The present study suggests that a low GH level at admission and the absence of its decrease after weight recovery could predict short-term relapse in women suffering from a restrictive form of AN.<\/jats:p>","DOI":"10.1017\/s000711451200431x","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T05:10:26Z","timestamp":1351833026000},"page":"2175-2181","source":"Crossref","is-referenced-by-count":23,"title":["Growth hormone level at admission and its evolution during refeeding are predictive of short-term outcome in restrictive anorexia nervosa"],"prefix":"10.1017","volume":"109","author":[{"given":"Juan 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