{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T21:18:59Z","timestamp":1775855939889,"version":"3.50.1"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2013,8,28]]},"abstract":"<jats:p>Lactose malabsorption is associated with rapid production of high levels of osmotic compounds, such as organic acids and SCFA in the colon, suspected to contribute to the onset of lactose intolerance. Adult rats are lactase deficient and the present study was conducted to evaluate<jats:italic>in vivo<\/jats:italic>the metabolic consequences of acute lactose ingestion, including host\u2013microbiota interactions. Rats received diets of 25\u00a0% sucrose (S25 control group) or 25\u00a0% lactose (L25 experimental group). SCFA and lactic acid were quantified in intestinal contents and portal blood. Expression of SCFA transporter genes was quantified in the colonic mucosa. Carbohydrate oxidation (Cox) and lipid oxidation (Lox) were computed by indirect calorimetry. Measurements were performed over a maximum of 13\u00a0h. Time, diet and time\u00a0\u00d7\u00a0diet variables had significant effects on SCFA concentration in the caecum (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b7001,<jats:italic>P<\/jats:italic>=\u00a00\u00b7004 and<jats:italic>P<\/jats:italic>=\u00a00\u00b7007, respectively) and the portal blood (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b7001,<jats:italic>P<\/jats:italic>=\u00a00\u00b704 and<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b7001, respectively). Concomitantly, expression of sodium monocarboxylate significantly increased in the colonic mucosa of the L25 group (<jats:italic>P<\/jats:italic>=\u00a00\u00b7003 at<jats:italic>t<\/jats:italic>=\u00a06\u00a0h and<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705 at<jats:italic>t<\/jats:italic>=\u00a08\u00a0h). During 5\u00a0h after the meal, the L25 group's changes in metabolic parameters (Cox, Lox) were significantly lower than those of the S25 group (<jats:italic>P<\/jats:italic>=\u00a00\u00b702). However, after 5\u00a0h, L25 Cox became greater than S25 (<jats:italic>P<\/jats:italic>=\u00a00\u00b7004). Thus, enhanced production and absorption of SCFA support the metabolic changes observed in calorimetry. These results underline the consequences of acute lactose malabsorption and measured compensations occurring in the host's metabolism, presumably through the microbiota fermentations and microbiota\u2013host interactions.<\/jats:p>","DOI":"10.1017\/s0007114512005557","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T15:37:37Z","timestamp":1358264257000},"page":"625-631","source":"Crossref","is-referenced-by-count":21,"title":["Lactose malabsorption and colonic fermentations alter host metabolism in rats"],"prefix":"10.1017","volume":"110","author":[{"given":"Virginie","family":"Alexandre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick 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