{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:43:08Z","timestamp":1786999388385,"version":"build-2736575974"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T00:00:00Z","timestamp":1358121600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2013,8,28]]},"abstract":"<jats:p>\n                    High prevalence of hypothyroxinaemia in iodine-deficient (ID) mothers has serious implications for mental health of the progeny. Independent supplementation of iodine and\n                    <jats:italic>n<\/jats:italic>\n                    -3 fatty acids (FA) markedly improves growth and cognitive performance of school children. Discerning effects of\n                    <jats:italic>n<\/jats:italic>\n                    -3 FA and iodine on the developing cerebellum have not been ascertained. The present study investigates effects of these two micronutrients separately as well as together in an ID rat model. We studied the effects of these micronutrients on progeny of ID dams by instituting the following supplementation diets: (1) low-iodine diet (LID), (2) LID+potassium iodide (KI), (3) LID+\n                    <jats:italic>n<\/jats:italic>\n                    -3 FA and (4) LID+KI+\n                    <jats:italic>n<\/jats:italic>\n                    -3 FA. Pups were investigated for morphological and biochemical parameters at the peak of cerebellar histogenesis on postnatal day (P) 16 and for neurobehavioural as well as motor coordination parameters at P40. Results indicate that\n                    <jats:italic>n<\/jats:italic>\n                    -3 FA alone, without improvement in circulating thyroid hormone (TH), significantly improves functional, morphological and biochemical indices of the developing cerebellum. Further, results show that co-supplementation with iodine and\n                    <jats:italic>n<\/jats:italic>\n                    -3 FA rescues not only the loss of neurotrophic support, but also salvages motor coordination, memory and learning. This additive effect results in significantly improving neurotrophic support and seems to be mediated by parallel significant increase in TH receptor (TR)\u03b1 and normalisation of TR\u03b2, retinoic orphan receptor \u03b1 and p75 neurotrophin receptor, as well as noteworthy prevention of apoptotic cell death and strengthening of anti-oxidative defence. The overall results indicate important mitigating role that\n                    <jats:italic>n<\/jats:italic>\n                    -3 FA may play in enhancing TH nuclear receptor-mediated signalling in the developing cerebellum.\n                  <\/jats:p>","DOI":"10.1017\/s0007114512005569","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T05:02:19Z","timestamp":1358139739000},"page":"659-670","source":"Crossref","is-referenced-by-count":9,"title":["Iodine plus\n                    <i>n<\/i>\n                    -3 fatty acid supplementation augments rescue of postnatal neuronal abnormalities in iodine-deficient rat cerebellum"],"prefix":"10.1017","volume":"110","author":[{"given":"Amit","family":"Pal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishwa","family":"Mohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh R.","family":"Modi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit A.","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Rastogi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madan M.","family":"Godbole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,1,14]]},"reference":[{"key":"S0007114512005569_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2011.09.006"},{"key":"S0007114512005569_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"S0007114512005569_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2010.02.007"},{"key":"S0007114512005569_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2009.02.003"},{"key":"S0007114512005569_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.12.012"},{"key":"S0007114512005569_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-1035-8"},{"key":"S0007114512005569_ref14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"S0007114512005569_ref3","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2008.0341"},{"key":"S0007114512005569_ref34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.062413299"},{"key":"S0007114512005569_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.05.012"},{"key":"S0007114512005569_ref23","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e328347881b"},{"key":"S0007114512005569_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(84)90007-4"},{"key":"S0007114512005569_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91102-2"},{"key":"S0007114512005569_ref37","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/17.2.455"},{"key":"S0007114512005569_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.02.010"},{"key":"S0007114512005569_ref38","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.601"},{"key":"S0007114512005569_ref33","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.3.623"},{"key":"S0007114512005569_ref5","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1760039"},{"key":"S0007114512005569_ref31","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.133.3.631"},{"key":"S0007114512005569_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2010.01.005"},{"key":"S0007114512005569_ref16","first-page":"201","article-title":"A modified spectrophotometric assay of superoxide dismutase using nitrite formation of superoxide radicals","volume":"37","author":"Das","year":"2000","journal-title":"Indian J Biochem Biophys"},{"key":"S0007114512005569_ref10","doi-asserted-by":"crossref","first-page":"11683","DOI":"10.1016\/S0021-9258(17)32624-8","article-title":"A novel heterodimerization partner for thyroid hormone receptor. 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