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Groups II, III and IV received an oral administration of TCE at a dose of 1000\u00a0mg\/kg body weight for twenty consecutive days. The animals in groups II and III received an oral treatment of DM at doses of 20 and 40\u00a0mg\/kg body weight, respectively, for twenty consecutive days, while groups I and V were given maize oil (5\u00a0ml\/kg body weight and DM 40\u00a0mg\/kg body weight, respectively) for 20\u00a0d. The protective effects of DM on TCE-induced oxidative stress and caspase-dependent apoptosis were investigated by assaying oxidative stress biomarkers, lipid peroxidation (LPO), serum toxicity markers, alkaline unwinding assay, caspase-3, -7 and -9, Bax and p53 expression. Oral administration of TCE in rats enhanced renal LPO, depleted glutathione content and antioxidant enzymes, induced DNA strand breaks (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b7001), modulated the expression of Bax and p53 protein and induced the expression of caspase-3, -7 and -9. Co-treatment with DM prevented oxidative stress by restoring the levels of antioxidant enzymes; furthermore, a significant dose-dependent decrease in DNA disintegration and kidney toxicity markers such as blood urea N, creatinine, lactate dehydrogenase and kidney injury molecule-1 was observed. DM also effectively decreased the TCE-induced up-regulation of Bax and p53. Data from the present study establish the protective role of DM against TCE-induced renal damage.<\/jats:p>","DOI":"10.1017\/s0007114512005752","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T13:40:39Z","timestamp":1360676439000},"page":"699-710","source":"Crossref","is-referenced-by-count":63,"title":["Diosmin protects against trichloroethylene-induced renal injury in Wistar rats: plausible role of p53, Bax and caspases"],"prefix":"10.1017","volume":"110","author":[{"given":"Muneeb U.","family":"Rehman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mir","family":"Tahir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Quaiyoom 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