{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:43:08Z","timestamp":1778524988145,"version":"3.51.4"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T00:00:00Z","timestamp":1368057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2013,11,28]]},"abstract":"<jats:p>Coeliac disease is an autoimmune disorder triggered by gluten intake, causing intestinal inflammation and mucosal damage commonly associated with the malabsorption of nutrients and ferropenic anaemia. The present study evaluates the effects of the oral administration of<jats:italic>Bifidobacterium longum<\/jats:italic>CECT 7347 on gliadin-mediated alterations in hepatic Fe deposition and Hb concentration, liver transferrin receptor (TfR)-2, IL-6, TNF-\u03b1 and hepcidin (<jats:italic>Hamp<\/jats:italic>) expression (mRNA), and active hepcidin peptide production by liquid chromatography\u2013MS\/MS. Weanling rats, sensitised or not with interferon (IFN)-\u03b3, were fed with gliadins and\/or the bifidobacterial strain. Gliadin feeding increased hepatic Fe deposition; however, only gliadin-fed sensitised animals showed lower Hb concentrations than the controls.<jats:italic>TfR2<\/jats:italic>expression decreased after gliadins were fed to both sensitised and non-sensitised animals, and restored by the administration of<jats:italic>B. longum<\/jats:italic>. These observations were accompanied by increases in<jats:italic>IL-6<\/jats:italic>expression levels in all the treatment groups; however,<jats:italic>TNF-\u03b1<\/jats:italic>expression only increased significantly in animals fed gliadins alone or together with<jats:italic>B. longum<\/jats:italic>if they had previously been sensitised with IFN-\u03b3. Liver expression levels of<jats:italic>Hamp<\/jats:italic>diminished in all cases to the lowest values in animals sensitised with IFN-\u03b3 after being fed with gliadins and\/or bifidobacteria. In these animals, plasma<jats:italic>Hamp<\/jats:italic>active peptide concentrations significantly increased when compared with the controls. Significant correlations were calculated between<jats:italic>Hamp<\/jats:italic>expression and liver Fe contents (liver Fe\u00a0=\u00a01\/0\u00b70032+0\u00b7032\u00a0\u00d7\u00a0<jats:italic>Hamp<\/jats:italic><jats:sub>exp<\/jats:sub>), and Hb concentrations (Hb\u00a0=\u00a011\u00b749+10\u00b713\u00a0\u00d7\u00a0(<jats:italic>Hamp<\/jats:italic><jats:sub>exp<\/jats:sub>)<jats:sup>1\/2<\/jats:sup>). These data indicate that oral administration of<jats:italic>B. longum<\/jats:italic>ameliorates gliadin-mediated perturbations in liver Fe deposition and mobilisation.<\/jats:p>","DOI":"10.1017\/s0007114513001098","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T08:47:24Z","timestamp":1368089244000},"page":"1828-1836","source":"Crossref","is-referenced-by-count":20,"title":["Oral administration of<i>Bifidobacterium longum<\/i>CECT 7347 ameliorates gliadin-induced alterations in liver iron mobilisation"],"prefix":"10.1017","volume":"110","author":[{"given":"Jos\u00e9 Mois\u00e9s","family":"Laparra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Olivares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,5,9]]},"reference":[{"key":"S0007114513001098_ref16","volume-title":"Fisiolog\u00eda m\u00e9dica (Review of Medical Physiology)","author":"Ganong","year":"1990"},{"key":"S0007114513001098_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00365-11"},{"key":"S0007114513001098_ref22","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i41.6585"},{"key":"S0007114513001098_ref13","doi-asserted-by":"publisher","DOI":"10.1021\/jf201212m"},{"key":"S0007114513001098_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/122.10.2047"},{"key":"S0007114513001098_ref34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008922200"},{"key":"S0007114513001098_ref5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4049\/jimmunol.153.2.499","article-title":"In vivo T cell activation by anti-CD3 monoclonal antibody induces soluble TNF receptor release in mice. Effects of pentoxifylline, methylprednisolone, anti-TNF, and anti-IFN-gamma antibodies","volume":"153","author":"Bemelmans","year":"1994","journal-title":"J Immunol"},{"key":"S0007114513001098_ref40","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2006.079186"},{"key":"S0007114513001098_ref21","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42011"},{"key":"S0007114513001098_ref27","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008923200"},{"key":"S0007114513001098_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.06.057"},{"key":"S0007114513001098_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.07.081"},{"key":"S0007114513001098_ref11","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jcb.22459","article-title":"Bifidobacteria inhibit the inflammatory response induced by gliadins in intestinal epithelial cells via modifications of toxic peptide generation during digestion","volume":"109","author":"Laparra","year":"2010","journal-title":"J Cell Biochem"},{"key":"S0007114513001098_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-6445(03)00055-X"},{"key":"S0007114513001098_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840180420"},{"key":"S0007114513001098_ref45","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2000.278.6.G886"},{"key":"S0007114513001098_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2010.08.005"},{"key":"S0007114513001098_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200210000-00010"},{"key":"S0007114513001098_ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-5-19"},{"key":"S0007114513001098_ref26","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.117077"},{"key":"S0007114513001098_ref30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016169"},{"key":"S0007114513001098_ref33","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.010322"},{"key":"S0007114513001098_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/ar565"},{"key":"S0007114513001098_ref9","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47410-0"},{"key":"S0007114513001098_ref28","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.148643"},{"key":"S0007114513001098_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2008.01.006"},{"key":"S0007114513001098_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.02.004"},{"key":"S0007114513001098_ref32","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-11-057471"},{"key":"S0007114513001098_ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-57"},{"key":"S0007114513001098_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840190623"},{"key":"S0007114513001098_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2009.01.010"},{"key":"S0007114513001098_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.06.006"},{"key":"S0007114513001098_ref35","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.318.7177.164"},{"key":"S0007114513001098_ref41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200420945"},{"key":"S0007114513001098_ref42","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.3.1253"},{"key":"S0007114513001098_ref36","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26589"},{"key":"S0007114513001098_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-006-0023-7"},{"key":"S0007114513001098_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030744"},{"key":"S0007114513001098_ref1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.09.008"},{"key":"S0007114513001098_ref20","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0672"},{"key":"S0007114513001098_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.061366"},{"key":"S0007114513001098_ref25","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510004046"},{"key":"S0007114513001098_ref39","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04516.x"},{"key":"S0007114513001098_ref43","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1016\/S0021-9258(18)32158-6","article-title":"Purification of a factor inducing differentiation in murine myelomonocytic leukemia cells. Identification as granulocyte colony-stimulating factor","volume":"258","author":"Nicola","year":"1983","journal-title":"J Biol Chem"},{"key":"S0007114513001098_ref31","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114513001098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T11:28:08Z","timestamp":1715340488000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114513001098\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,9]]},"references-count":45,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,11,28]]}},"alternative-id":["S0007114513001098"],"URL":"https:\/\/doi.org\/10.1017\/s0007114513001098","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,9]]}}}