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To determine whether lycopene supplementation can regulate adipokine expression in obesity, male Wistar rats were randomly assigned to receive a control diet (C,<jats:italic>n<\/jats:italic>6) or a hyperenergetic diet (DIO,<jats:italic>n<\/jats:italic>12) for 6 weeks. After this period, the DIO animals were randomised into two groups: DIO (<jats:italic>n<\/jats:italic>6) and DIO supplemented with lycopene (DIO+L,<jats:italic>n<\/jats:italic>6). The animals received maize oil (C and DIO) or lycopene (DIO+L, 10\u00a0mg\/kg body weight (BW) per d) by oral administration for a 6-week period. The animals were then killed by decapitation, and blood samples and epididymal adipose tissue were collected for hormonal determination and gene expression evaluation (<jats:italic>IL-6<\/jats:italic>, monocyte chemoattractant protein-1 (<jats:italic>MCP-1<\/jats:italic>),<jats:italic>TNF-\u03b1<\/jats:italic>, leptin and resistin). There was no detectable lycopene in the plasma of the C and DIO groups. However, the mean lycopene plasma concentration was 24\u00a0nmol in the DIO+L group. Although lycopene supplementation did not affect BW or adiposity, it significantly decreased leptin, resistin and<jats:italic>IL-6<\/jats:italic>gene expression in epididymal adipose tissue and plasma concentrations. Also, it significantly reduced the gene expression of<jats:italic>MCP-1<\/jats:italic>in epididymal adipose tissue. Lycopene affects adipokines by reducing leptin, resistin and plasma IL-6 levels. These data suggest that lycopene may be an effective strategy in reducing inflammation in obesity.<\/jats:p>","DOI":"10.1017\/s0007114513001256","type":"journal-article","created":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T15:19:26Z","timestamp":1367421566000},"page":"1803-1809","source":"Crossref","is-referenced-by-count":97,"title":["Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and<i>IL-6<\/i>in diet-induced obese rats"],"prefix":"10.1017","volume":"110","author":[{"given":"Renata de Azevedo Melo","family":"Luvizotto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre F.","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Imaizumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damiana 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