{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:44:04Z","timestamp":1793933044152,"version":"4.8.0"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T00:00:00Z","timestamp":1369267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2013,12,28]]},"abstract":"<jats:p>Dietary polyphenols, such as those from grape products, may exert beneficial effects on cardiovascular health, including anti-hypertensive effects. We investigated the effect of a specific grape seed extract (GSE) rich in low-molecular-weight polyphenolic compounds on ambulatory blood pressure (ABP) in untreated subjects with pre- and stage I hypertension. In addition, potential mechanisms that could underlie the hypothesised effect of GSE on blood pressure (BP), and platelet aggregation, were explored. The study was designed as a double-blind, placebo-controlled, randomised, parallel-group intervention study including seventy healthy subjects with systolic BP between 120 and 159\u00a0mmHg. A 1-week run-in period was followed by an 8-week intervention period, during which subjects consumed capsules containing either 300\u00a0mg\/d of GSE or a placebo (microcrystalline cellulose). Before and after the intervention, daytime ABP readings, 24\u00a0h urine samples and fasting and non-fasting blood samples were taken. The mean baseline systolic BP was 135\u00b78 (<jats:sc>se<\/jats:sc> 1\u00b73)\u00a0mmHg and diastolic BP was 81\u00b75 (<jats:sc>se<\/jats:sc> 0\u00b79)\u00a0mmHg. BP values were modestly, but not significantly, affected by the polyphenol-rich GSE treatment <jats:italic>v<\/jats:italic>. placebo with an effect of \u2212\u00a03\u00b70\u00a0mmHg for systolic BP (95\u00a0% CI \u2212\u00a06\u00b75, 0\u00b75) and \u2212\u00a01\u00b74\u00a0mmHg for diastolic BP (95\u00a0% CI \u2212\u00a03\u00b75, 0\u00b76). Vasoactive markers including endothelin-1, NO metabolites and asymmetric dimethylarginine, plasma renin activity and platelet aggregation were not affected by the GSE intervention. Our findings show that consumption of polyphenol-rich GSE does not significantly lower ABP in untreated subjects with pre- and stage I hypertension.<\/jats:p>","DOI":"10.1017\/s000711451300161x","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T13:30:46Z","timestamp":1369315846000},"page":"2234-2241","source":"Crossref","is-referenced-by-count":79,"title":["Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension"],"prefix":"10.1017","volume":"110","author":[{"given":"Rouyanne T.","family":"Ras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter L.","family":"Zock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne E. M. 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