{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:44:38Z","timestamp":1780519478931,"version":"3.54.1"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2014,3,28]]},"abstract":"<jats:p>Fruit and vegetables are key elements of a cardioprotective diet, but benefits on plasma lipids, especially HDL-cholesterol (HDL-C), are inconsistent both within and between studies. In the present study, we investigated whether four selected HDL-C-related polymorphisms (cholesteryl ester transfer protein (<jats:italic>CETP<\/jats:italic>) <jats:italic>Taq1B<\/jats:italic>, <jats:italic>APOA1<\/jats:italic> \u2212\u00a075G\/A, hepatic lipase (<jats:italic>LIPC<\/jats:italic>) \u2212\u00a0514C\u00a0\u2192\u00a0T, and endothelial lipase (<jats:italic>LIPG<\/jats:italic>) I24582) modulate the plasma lipid response to a kiwifruit intervention. This is a retrospective analysis of data collected during a 12-week randomised controlled cross-over trial. A total of eighty-five hypercholesterolaemic men completed a 4-week healthy diet run-in period before being randomised to one of two 4-week intervention sequences of two green kiwifruit\/d plus healthy diet (kiwifruit intervention) or healthy diet alone (control intervention). The measurement of anthropometric parameters and collection of fasting blood samples were carried out at baseline 1 and after the run-in (baseline 2) and intervention periods. At baseline 2, <jats:italic>B1\/B1<\/jats:italic> homozygotes of the <jats:italic>CETP<\/jats:italic><jats:italic>Taq1B<\/jats:italic> gene had significantly higher total cholesterol:HDL-C, TAG:HDL-C, and apoB:apoA1 ratios and small-dense LDL concentrations than <jats:italic>B2<\/jats:italic> carriers. A significant <jats:italic>CETP Taq1B<\/jats:italic> genotype\u00a0\u00d7\u00a0intervention interaction was observed for the TAG:HDL-C ratio (<jats:italic>P<\/jats:italic>=\u00a00\u00b703). <jats:italic>B1\/B1<\/jats:italic> homozygotes had a significantly lower TAG:HDL-C (\u00a0\u2212\u00a00\u00b723 (<jats:sc>sd<\/jats:sc> 0\u00b758)\u00a0mmol\/l; <jats:italic>P<\/jats:italic>=\u00a00\u00b703) ratio after the kiwifruit intervention than after the control intervention, whereas the ratio of <jats:italic>B2<\/jats:italic> carriers was not affected. The lipid response was not affected by other gene polymorphisms. In conclusion, the significant decrease in the TAG:HDL-C ratio in <jats:italic>B1\/B1<\/jats:italic> homozygotes suggests that regular inclusion of green kiwifruit as part of a healthy diet may improve the lipid profiles of hypercholesterolaemic men with this genotype.<\/jats:p>","DOI":"10.1017\/s0007114513003437","type":"journal-article","created":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T13:02:20Z","timestamp":1383310940000},"page":"1077-1084","source":"Crossref","is-referenced-by-count":16,"title":["<i>TaqIB<\/i> polymorphism in the cholesteryl ester transfer protein (<i>CETP<\/i>) gene influences lipid responses to the consumption of kiwifruit in hypercholesterolaemic men"],"prefix":"10.1017","volume":"111","author":[{"given":"Cheryl S.","family":"Gammon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Minihane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozanne","family":"Kruger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathryn A.","family":"Conlon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela R.","family":"von Hurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrix","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Welma","family":"Stonehouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"S0007114513003437_ref34","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700319"},{"key":"S0007114513003437_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990129)82:3<235::AID-AJMG8>3.0.CO;2-H"},{"key":"S0007114513003437_ref31","first-page":"757","article-title":"Lipoprotein ratios: physiological significance and clinical usefulness in cardiovascular prevention","volume":"5","author":"Millan","year":"2009","journal-title":"Vasc Health Risk Manag"},{"key":"S0007114513003437_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2010.03.018"},{"key":"S0007114513003437_ref21","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.6.1487"},{"key":"S0007114513003437_ref7","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P008268"},{"key":"S0007114513003437_ref26","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000054658.91146.64"},{"key":"S0007114513003437_ref8","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510003922"},{"key":"S0007114513003437_ref28","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R027011"},{"key":"S0007114513003437_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2006.11.025"},{"key":"S0007114513003437_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.07.008"},{"key":"S0007114513003437_ref29","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R200018-JLR200"},{"key":"S0007114513003437_ref11","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R400007-JLR200"},{"key":"S0007114513003437_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2003.12.001"},{"key":"S0007114513003437_ref36","doi-asserted-by":"publisher","DOI":"10.3109\/09637480903517788"},{"key":"S0007114513003437_ref1","volume-title":"Cardiovascular Diseases Fact Sheet no. 317","year":"2011"},{"key":"S0007114513003437_ref35","doi-asserted-by":"publisher","DOI":"10.1021\/jf900210z"},{"key":"S0007114513003437_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201362"},{"key":"S0007114513003437_ref33","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182160726"},{"key":"S0007114513003437_ref17","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/ajcn\/81.6.1429","article-title":"Interactions between the \u2212\u00a0514C->T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men","volume":"81","author":"Zhang","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"S0007114513003437_ref5","doi-asserted-by":"publisher","DOI":"10.2217\/17460875.2.5.557"},{"key":"S0007114513003437_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2009.03.012"},{"key":"S0007114513003437_ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304223281603"},{"key":"S0007114513003437_ref13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.23.2777"},{"key":"S0007114513003437_ref9","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.131"},{"key":"S0007114513003437_ref22","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108083250601"},{"key":"S0007114513003437_ref30","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.9.6.747"},{"key":"S0007114513003437_ref39","doi-asserted-by":"publisher","DOI":"10.1017\/S0029665112002856"},{"key":"S0007114513003437_ref25","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/ajcn\/75.1.38","article-title":"Polyunsaturated fatty acids modulate the effects of the APOA1 G-A polymorphism on HDL-cholesterol concentrations in a sex-specific manner: the Framingham Study","volume":"75","author":"Ordovas","year":"2002","journal-title":"Am J Clin Nutr"},{"key":"S0007114513003437_ref16","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000036597.52291.C9"},{"key":"S0007114513003437_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114512004400"},{"key":"S0007114513003437_ref2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R001610"},{"key":"S0007114513003437_ref3","doi-asserted-by":"publisher","DOI":"10.1185\/030079906X104821"},{"key":"S0007114513003437_ref12","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000153341.46271.40"},{"key":"S0007114513003437_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.05.029"},{"key":"S0007114513003437_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-010-3408-1"},{"key":"S0007114513003437_ref38","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283414e71"},{"key":"S0007114513003437_ref27","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp399"},{"key":"S0007114513003437_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2008.09.026"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114513003437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T22:31:44Z","timestamp":1555972304000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114513003437\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,1]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,3,28]]}},"alternative-id":["S0007114513003437"],"URL":"https:\/\/doi.org\/10.1017\/s0007114513003437","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,1]]}}}