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In the present study, we reviewed the safety of SIF in relation to anthropometric growth, bone health (bone mineral content), immunity, cognition, and reproductive and endocrine functions. The present review includes cross-sectional, case\u2013control, cohort studies or clinical trials that were carried out in children fed SIF compared with those fed other types of infant formulas and that measured safety. The databases that were searched included PubMed (1909 to July 2013), Embase (1988 to May 2013), LILACS (1990 to May 2011), ARTEMISA (13th edition, December 2012), Cochrane controlled trials register, Bandolier and DARE using the Cochrane methodology. Wherever possible, a meta-analysis was carried out. We found that the anthropometric patterns of children fed SIF were similar to those of children fed CMF or HM. Despite the high levels of phytates and aluminium in SIF, Hb, serum protein, Zn and Ca concentrations and bone mineral content were found to be similar to those of children fed CMF or HM. We also found the levels of genistein and daidzein to be higher in children fed SIF; however, we did not find strong evidence of a negative effect on reproductive and endocrine functions. Immune measurements and neurocognitive parameters were similar in all the feeding groups. In conclusion, modern SIF are evidence-based safety options to feed children requiring them. The patterns of growth, bone health and metabolic, reproductive, endocrine, immune and neurological functions are similar to those observed in children fed CMF or HM.<\/jats:p>","DOI":"10.1017\/s0007114513003942","type":"journal-article","created":{"date-parts":[[2014,2,10]],"date-time":"2014-02-10T08:48:29Z","timestamp":1392022109000},"page":"1340-1360","source":"Crossref","is-referenced-by-count":87,"title":["Safety of soya-based infant formulas in children"],"prefix":"10.1017","volume":"111","author":[{"given":"Yvan","family":"Vandenplas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Gutierrez","family":"Castrellon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Jimenez","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa Diaz","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Estevez","family":"Jimenez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahi","family":"Anzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badriul","family":"Hegar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Alarcon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,2,10]]},"reference":[{"key":"S0007114513003942_ref147","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.12.067"},{"key":"S0007114513003942_ref103","doi-asserted-by":"publisher","DOI":"10.1185\/03007990802594685"},{"key":"S0007114513003942_ref63","doi-asserted-by":"crossref","first-page":"654S","DOI":"10.1093\/jn\/130.3.654S","article-title":"Absorption and metabolism of soy isoflavones \u2013 from food to dietary supplements and adults to infants","volume":"130","author":"Setchell","year":"2000","journal-title":"J Nutr"},{"key":"S0007114513003942_ref161","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/archpedi.1986.02140260065028","article-title":"Premature thelarche in Puerto Rico","volume":"140","author":"Lambertina","year":"1986","journal-title":"Am J Dis Child"},{"key":"S0007114513003942_ref94","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31815c40ab"},{"key":"S0007114513003942_ref49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3038.1997.tb00146.x"},{"key":"S0007114513003942_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7056.507"},{"key":"S0007114513003942_ref86","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3280fa821b"},{"key":"S0007114513003942_ref105","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2009.01011.x"},{"key":"S0007114513003942_ref79","first-page":"351","article-title":"Palatability of hydrolysates and other substitution formulas for cow's milk-allergic children: a comparative study of taste, smell, and texture evaluated by healthy volunteer","volume":"16","author":"Pedrosa","year":"2006","journal-title":"J Investig Allergol Clin Immunol"},{"key":"S0007114513003942_ref150","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3121"},{"key":"S0007114513003942_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80689-4"},{"key":"S0007114513003942_ref109","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2010.29394"},{"key":"S0007114513003942_ref144","doi-asserted-by":"publisher","DOI":"10.1177\/000992289903801001"},{"key":"S0007114513003942_ref85","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507771866"},{"key":"S0007114513003942_ref34","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.1.87"},{"key":"S0007114513003942_ref151","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90004-1"},{"key":"S0007114513003942_ref41","first-page":"209","article-title":"Clinical evaluation of the tolerance for a soy-based special milk formula in children with cow's milk protein intolerance\/allergy (CMPI\/CMPA)","volume":"45","author":"Buts","year":"1993","journal-title":"Minerva Pediatr"},{"key":"S0007114513003942_ref6","unstructured":"USDA (2002) USDA-Iowa State University database on the isoflavone content of food, Release 1.3. http:\/\/www.nal.usda.gov\/fnic\/foodcomp\/Data\/isoflav\/isoflav.html. 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