{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T21:54:19Z","timestamp":1791150859022,"version":"4.1.0"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T00:00:00Z","timestamp":1398643200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2014,7,14]]},"abstract":"<jats:p>Interactions between the immune system and the intestinal microbiota may play a role in coeliac disease (CD). In the present study, the potential effects of<jats:italic>Bifidobacterium longum<\/jats:italic>CECT 7347 in children with newly diagnosed CD were evaluated. A double-blind, randomised, placebo-controlled trial was conducted in thirty-three children who received a capsule containing either<jats:italic>B. longum<\/jats:italic>CECT 7347 (10<jats:sup>9<\/jats:sup>colony-forming units) or placebo (excipients) daily for 3 months together with a gluten-free diet (GFD). Outcome measures (baseline and post-intervention) included immune phenotype of peripheral blood cells, serum cytokine concentration, faecal secretory IgA (sIgA) content, anthropometric parameters and intestinal microbiota composition. Comparisons between the groups revealed greater height percentile increases (<jats:italic>P<\/jats:italic>=\u00a00\u00b7048) in the<jats:italic>B. longum<\/jats:italic>CECT 7347 group than in the placebo group, as well as decreased peripheral CD3<jats:sup>+<\/jats:sup>T lymphocytes (<jats:italic>P<\/jats:italic>=\u00a00\u00b7004) and slightly reduced TNF-\u03b1 concentration (<jats:italic>P<\/jats:italic>=\u00a00\u00b7067). Within-group comparisons of baseline and final values did not reveal any differences in T lymphocytes and cytokines in the placebo group, while decreased CD3<jats:sup>+<\/jats:sup>(<jats:italic>P\u00a0=<\/jats:italic>0\u00b7013) and human leucocyte antigen (HLA)-DR<jats:sup>+<\/jats:sup>T lymphocytes (<jats:italic>P\u00a0=<\/jats:italic>0\u00b7029) and slightly reduced TNF-\u03b1 concentration (<jats:italic>P<\/jats:italic>=\u00a00\u00b7085) were detected in the<jats:italic>B. longum<\/jats:italic>CECT 7347 group. Comparison between the groups showed that the administration of<jats:italic>B. longum<\/jats:italic>CECT 7347 reduced the numbers of the<jats:italic>Bacteroides fragilis<\/jats:italic>group (<jats:italic>P<\/jats:italic>=\u00a00\u00b7020) and the content of sIgA in stools (<jats:italic>P<\/jats:italic>=\u00a00\u00b7011) compared with the administration of placebo. Although this is a first exploratory intervention with limitations, the findings suggest that<jats:italic>B. longum<\/jats:italic>CECT 7347 could help improve the health status of CD patients who tend to show alterations in gut microbiota composition and a biased immune response even on a GFD.<\/jats:p>","DOI":"10.1017\/s0007114514000609","type":"journal-article","created":{"date-parts":[[2014,4,28]],"date-time":"2014-04-28T12:43:06Z","timestamp":1398688986000},"page":"30-40","source":"Crossref","is-referenced-by-count":136,"title":["Double-blind, randomised, placebo-controlled intervention trial to evaluate the effects of<i>Bifidobacterium longum<\/i>CECT 7347 in children with newly diagnosed coeliac disease"],"prefix":"10.1017","volume":"112","author":[{"given":"Marta","family":"Olivares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Castillejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Varea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,4,28]]},"reference":[{"key":"S0007114514000609_ref40","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6941.12186"},{"key":"S0007114514000609_ref32","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199411000-00005"},{"key":"S0007114514000609_ref30","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/7.6.1513"},{"key":"S0007114514000609_ref28","volume-title":"Tablas de composici\u00f3n de alimentos CESNID (CESNID Food Composition Tables)","author":"Farran","year":"2004"},{"key":"S0007114514000609_ref36","doi-asserted-by":"publisher","DOI":"10.1038\/ncpgasthep0259"},{"key":"S0007114514000609_ref44","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e31827759ac"},{"key":"S0007114514000609_ref34","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e318187189e"},{"key":"S0007114514000609_ref22","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2010.516448"},{"key":"S0007114514000609_ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1998.00651.x"},{"key":"S0007114514000609_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04787.x"},{"key":"S0007114514000609_ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1363-6"},{"key":"S0007114514000609_ref27","doi-asserted-by":"publisher","DOI":"10.2174\/1389557510909030359"},{"key":"S0007114514000609_ref14","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1111581"},{"key":"S0007114514000609_ref10","doi-asserted-by":"publisher","DOI":"10.1186\/1476-9255-5-19"},{"key":"S0007114514000609_ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030744"},{"key":"S0007114514000609_ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-10-63"},{"key":"S0007114514000609_ref41","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2007.09.013"},{"key":"S0007114514000609_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.12.022"},{"key":"S0007114514000609_ref5","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2013.775666"},{"key":"S0007114514000609_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31828029a9"},{"key":"S0007114514000609_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.09.030"},{"key":"S0007114514000609_ref38","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20265"},{"key":"S0007114514000609_ref31","doi-asserted-by":"publisher","DOI":"10.2298\/SARH0912632R"},{"key":"S0007114514000609_ref7","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2180-8-232"},{"key":"S0007114514000609_ref42","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217718"},{"key":"S0007114514000609_ref3","volume-title":"Celiac Disease. Chapter 7","author":"Laparra","year":"2013"},{"key":"S0007114514000609_ref8","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2011.599084"},{"key":"S0007114514000609_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60254-3"},{"key":"S0007114514000609_ref16","doi-asserted-by":"publisher","DOI":"10.1021\/jf201212m"},{"key":"S0007114514000609_ref2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/654143"},{"key":"S0007114514000609_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e318241cfa8"},{"key":"S0007114514000609_ref29","doi-asserted-by":"publisher","DOI":"10.1002\/bit.20347"},{"key":"S0007114514000609_ref35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02992.x"},{"key":"S0007114514000609_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2012.04.019"},{"key":"S0007114514000609_ref6","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.47410-0"},{"key":"S0007114514000609_ref39","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114509371767"},{"key":"S0007114514000609_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03036.x"},{"key":"S0007114514000609_ref15","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/jcb.22459","article-title":"Bifidobacteria inhibit the inflammatory response induced by gliadins in intestinal epithelial cells via modifications of toxic peptide generation during digestion","volume":"109","author":"Laparra","year":"2010","journal-title":"J Cell Biochem"},{"key":"S0007114514000609_ref13","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.00563-12"},{"key":"S0007114514000609_ref26","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181557e67"},{"key":"S0007114514000609_ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016169"},{"key":"S0007114514000609_ref21","doi-asserted-by":"publisher","DOI":"10.1159\/000116770"},{"key":"S0007114514000609_ref37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2011.04545.x"},{"key":"S0007114514000609_ref43","first-page":"37","article-title":"Immunomodulatory effects of probiotics in the intestinal tract","volume":"10","author":"Delcenserie","year":"2008","journal-title":"Curr Issues Mol Biol"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114514000609","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T06:28:44Z","timestamp":1716704924000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114514000609\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,28]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,7,14]]}},"alternative-id":["S0007114514000609"],"URL":"https:\/\/doi.org\/10.1017\/s0007114514000609","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,28]]}}}