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For this purpose, eighteen cross-bred (Landrace\u00a0\u00d7\u00a0Yorkshire) primiparous sows were fed a control (CON), DLM or HMTBA diet (<jats:italic>n<\/jats:italic>6 per diet) from 0 to 14\u00a0d post-partum. At postnatal day 14, piglets in the HMTBA group had higher body weight (<jats:italic>P<\/jats:italic>=\u00a00\u00b702) than those in the CON group, tended (<jats:italic>P<\/jats:italic>=\u00a00\u00b707) to be higher than those in the DLM group, and had higher (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705) mRNA abundance of jejunal fatty acid-binding protein 2, intestinal than those in the CON and DLM groups. Compared with the CON diet-fed sows, milk protein, non-fat solid, and lysine, histidine and ornithine concentrations decreased in the DLM diet-fed sows (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705), and milk fat, lactose, and cysteine and taurine concentrations increased in the HMTBA diet-fed sows (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705). Plasma homocysteine and urea N concentrations that averaged across time were increased (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705) in sows fed the DLM diet compared with those fed the CON diet. Metabolomic results based on<jats:sup>1<\/jats:sup>H NMR spectroscopy revealed that consumption of the HMTBA and DLM diets increased (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705) both sow plasma methionine and valine levels; however, consumption of the DLM diet led to lower (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705) plasma levels of lysine, tyrosine, glucose and acetate and higher (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705) plasma levels of citrate, lactate, formate, glycerol,<jats:italic>myo<\/jats:italic>-inositol and<jats:italic>N<\/jats:italic>-acetyl glycoprotein in sows. Collectively, neonatal growth and milk synthesis were regulated by dietary methionine levels and sources, which resulted in marked alterations in amino acid, lipid and glycogen metabolism.<\/jats:p>","DOI":"10.1017\/s0007114514004036","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T04:17:25Z","timestamp":1422850645000},"page":"585-595","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":20,"title":["Differences in plasma metabolomics between sows fed<scp>dl<\/scp>-methionine and its hydroxy analogue reveal a strong association of milk composition and neonatal growth with maternal methionine 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