{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:44:44Z","timestamp":1791423884836,"version":"4.3.3"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T00:00:00Z","timestamp":1422489600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2015,2,28]]},"abstract":"<jats:p>The purpose of the present study was to determine whether probiotic supplementation (<jats:italic>Lactobacillus casei<\/jats:italic> Shirota (LcS)) prevents diet-induced insulin resistance in human subjects. A total of seventeen healthy subjects were randomised to either a probiotic (<jats:italic>n<\/jats:italic> 8) or a control (<jats:italic>n<\/jats:italic> 9) group. The probiotic group consumed a LcS-fermented milk drink twice daily for 4 weeks, whereas the control group received no supplementation. Subjects maintained their normal diet for the first 3 weeks of the study, after which they consumed a high-fat (65\u00a0% of energy), high-energy (50\u00a0% increase in energy intake) diet for 7\u00a0d. Whole-body insulin sensitivity was assessed by an oral glucose tolerance test conducted before and after overfeeding. Body mass increased by 0\u00b76 (<jats:sc>se<\/jats:sc> 0\u00b72)\u00a0kg in the control group (<jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705) and by 0\u00b73 (<jats:sc>se<\/jats:sc> 0\u00b72)\u00a0kg in the probiotic group (<jats:italic>P<\/jats:italic>&gt;0\u00b705). Fasting plasma glucose concentrations increased following 7\u00a0d of overeating (control group: 5\u00b73 (<jats:sc>se<\/jats:sc> 0\u00b71) <jats:italic>v<\/jats:italic>. 5\u00b76 (<jats:sc>se<\/jats:sc> 0\u00b72)\u00a0mmol\/l before and after overfeeding, respectively, <jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705), whereas fasting serum insulin concentrations were maintained in both groups. Glucose AUC values increased by 10\u00a0% (from 817 (<jats:sc>se<\/jats:sc> 45) to 899 (<jats:sc>se<\/jats:sc> 39)\u00a0mmol\/l per 120\u00a0min, <jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705) and whole-body insulin sensitivity decreased by 27\u00a0% (from 5\u00b73 (<jats:sc>se<\/jats:sc> 1\u00b74) to 3\u00b79 (<jats:sc>se<\/jats:sc> 0\u00b79), <jats:italic>P<\/jats:italic>&lt;\u00a00\u00b705) in the control group, whereas normal insulin sensitivity was maintained in the probiotic group (4\u00b74 (<jats:sc>se<\/jats:sc> 0\u00b78) and 4\u00b75 (<jats:sc>se<\/jats:sc> 0\u00b79) before and after overeating, respectively (<jats:italic>P<\/jats:italic>&gt;0\u00b705). These results suggest that probiotic supplementation may be useful in the prevention of diet-induced metabolic diseases such as type 2 diabetes.<\/jats:p>","DOI":"10.1017\/s0007114514004097","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T02:33:01Z","timestamp":1422498781000},"page":"596-602","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":126,"title":["Probiotic supplementation prevents high-fat, overfeeding-induced insulin resistance in human subjects"],"prefix":"10.1017","volume":"113","author":[{"given":"Carl J.","family":"Hulston","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amelia A.","family":"Churnside","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle 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