{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:59:31Z","timestamp":1787990371248,"version":"build-2784847793"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T00:00:00Z","timestamp":1423612800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2015,7,14]]},"abstract":"<jats:p>Glucagon-like peptide-1 (GLP-1), which is produced and released from enteroendocrine L cells, plays pivotal roles in postprandial glycaemia. The ingestion of resistant maltodextrin (RMD), a water-soluble non-digestible saccharide, improves the glycaemic response. In the present study, we examined whether the continuous feeding of RMD to rats affected GLP-1 levels and glycaemic control. Male Sprague\u2013Dawley rats (6 weeks of age) were fed an American Institute of Nutrition (AIN)-93G-based diet containing either cellulose (5\u00a0%) as a control, RMD (2\u00b75 or 5\u00a0%), or fructo-oligosaccharides (FOS, 2\u00b75 or 5\u00a0%) for 7 weeks. During the test period, an intraperitoneal glucose tolerance test (IPGTT) was performed after 6 weeks. Fasting GLP-1 levels were significantly higher in the 5\u00a0% RMD group than in the control group after 6 weeks. The IPGTT results showed that the glycaemic response was lower in the 5\u00a0% RMD group than in the control group. Lower caecal pH, higher caecal tissue and content weights were observed in the RMD and FOS groups. Proglucagon mRNA levels were increased in the caecum and colon of both RMD and FOS groups, whereas caecal GLP-1 content was increased in the 5\u00a0% RMD group. In addition, a 1\u00a0h RMD exposure induced GLP-1 secretion in an enteroendocrine L-cell model, and single oral administration of RMD increased plasma GLP-1 levels in conscious rats. The present study demonstrates that continuous ingestion of RMD increased GLP-1 secretion and production in normal rats, which could be stimulated by its direct and indirect (enhanced gut fermentation) effects on GLP-1-producing cells, and contribute to improving glucose tolerance.<\/jats:p>","DOI":"10.1017\/s0007114514004322","type":"journal-article","created":{"date-parts":[[2015,2,11]],"date-time":"2015-02-11T14:20:48Z","timestamp":1423664448000},"page":"34-42","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":33,"title":["Resistant maltodextrin promotes fasting glucagon-like peptide-1 secretion and production together with glucose tolerance in rats"],"prefix":"10.1017","volume":"114","author":[{"given":"Tohru","family":"Hira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Ikee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumiko","family":"Kanahori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,2,11]]},"reference":[{"key":"S0007114514004322_ref34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04485.x"},{"key":"S0007114514004322_ref37","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.4.6643"},{"key":"S0007114514004322_ref12","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.26842"},{"key":"S0007114514004322_ref32","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.57.30"},{"key":"S0007114514004322_ref23","doi-asserted-by":"crossref","first-page":"838S","DOI":"10.1093\/jn\/127.5.838S","article-title":"Components of the AIN-93 diets as improvements in the AIN-76A diet","volume":"127","author":"Reeves","year":"1997","journal-title":"J Nutr"},{"key":"S0007114514004322_ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2011.01357.x"},{"key":"S0007114514004322_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-009-0062-6"},{"key":"S0007114514004322_ref25","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507691648"},{"key":"S0007114514004322_ref18","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06100"},{"key":"S0007114514004322_ref6","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1510"},{"key":"S0007114514004322_ref27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.90635.2008"},{"key":"S0007114514004322_ref2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00078.2012"},{"key":"S0007114514004322_ref31","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.5.1147"},{"key":"S0007114514004322_ref42","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1093\/jn\/127.1.130","article-title":"Selected indigestible oligosaccharides affect large bowel mass, cecal and fecal short-chain fatty acids, pH and microflora in rats","volume":"127","author":"Campbell","year":"1997","journal-title":"J Nutr"},{"key":"S0007114514004322_ref7","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-2275"},{"key":"S0007114514004322_ref13","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.58.423"},{"key":"S0007114514004322_ref19","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041342"},{"key":"S0007114514004322_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3148"},{"key":"S0007114514004322_ref39","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-014-9288-6"},{"key":"S0007114514004322_ref11","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.185298"},{"key":"S0007114514004322_ref35","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114513002286"},{"key":"S0007114514004322_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1498-0"},{"key":"S0007114514004322_ref41","doi-asserted-by":"publisher","DOI":"10.1021\/jf9024079"},{"key":"S0007114514004322_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.08.003"},{"key":"S0007114514004322_ref44","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.59.352"},{"key":"S0007114514004322_ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021113-170315"},{"key":"S0007114514004322_ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050658"},{"key":"S0007114514004322_ref17","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041225"},{"key":"S0007114514004322_ref28","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00155.2014"},{"key":"S0007114514004322_ref16","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2008.10719712"},{"key":"S0007114514004322_ref38","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1093\/jn\/127.5.758","article-title":"The protein digestibility-corrected amino acid score method overestimates quality of proteins containing antinutritional factors and of poorly digestible proteins supplemented with limiting amino acids in rats","volume":"127","author":"Sarwar","year":"1997","journal-title":"J Nutr"},{"key":"S0007114514004322_ref20","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2007.16"},{"key":"S0007114514004322_ref22","doi-asserted-by":"publisher","DOI":"10.2337\/db11-1019"},{"key":"S0007114514004322_ref10","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26362"},{"key":"S0007114514004322_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-012-2585-2"},{"key":"S0007114514004322_ref21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90637.2008"},{"key":"S0007114514004322_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-014-3305-x"},{"key":"S0007114514004322_ref29","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.148056"},{"key":"S0007114514004322_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2012.11.015"},{"key":"S0007114514004322_ref40","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1142"},{"key":"S0007114514004322_ref33","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.110936"},{"key":"S0007114514004322_ref36","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.191643"},{"key":"S0007114514004322_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-007-0643-1"},{"key":"S0007114514004322_ref24","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90207.2008"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114514004322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T22:12:29Z","timestamp":1555798349000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114514004322\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,11]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7,14]]}},"alternative-id":["S0007114514004322"],"URL":"https:\/\/doi.org\/10.1017\/s0007114514004322","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,11]]},"assertion":[{"value":"Copyright \u00a9 The Authors 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}