{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:45:33Z","timestamp":1791215133949,"version":"4.1.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2015,3,14]]},"abstract":"<jats:p>Women show higher vitamin C plasma concentrations than men, but the reasons for this observation still require elucidation. The objective of the present study was to investigate whether sex differences in vitamin C plasma concentrations are present in elderly subjects and whether these differences are due to sex-specific lifestyles, total antioxidant status (TAOS) and\/or body composition. Fasting plasma concentrations of vitamin C were assessed by photometric detection in a cross-sectional study of 181 women and eighty-nine men aged 62\u201392 years. Body composition was determined by bioelectrical impedance analysis. Vitamin C intake was assessed with a 3\u00a0d estimated dietary record. Stepwise multiple regression analyses were performed to investigate whether sex is an independent predictor of vitamin C plasma concentrations by controlling for age, vitamin C intake, lifestyle factors, TAOS and body composition. Women showed higher vitamin C plasma concentrations than men (76 <jats:italic>v<\/jats:italic>. 62\u00a0\u03bcmol\/l, <jats:italic>P<\/jats:italic>&lt;\u00a00\u00b70001). In the multiple regression analysis, male sex was a negative predictor of vitamin C plasma concentrations (\u03b2\u00a0=\u00a0\u2212\u00a00\u00b7214), as long as absolute fat-free mass (FFM) was not considered as a confounder. When absolute FFM was included, sex was no longer a predictor of vitamin C plasma concentrations, whereas absolute FFM (\u03b2\u00a0=\u00a0\u2212\u00a00\u00b7216), physical activity level (\u03b2\u00a0=\u00a00\u00b7165), intake of vitamin C supplements (\u03b2\u00a0=\u00a00\u00b7164), age (\u03b2\u00a0=\u00a00\u00b7147) and smoking (\u03b2\u00a0=\u00a0\u2212\u00a00\u00b7125) affected vitamin C plasma concentrations. The results indicate that a higher absolute FFM, and thus a higher distribution volume of vitamin C, contributes to lower vitamin C plasma concentrations in men than women.<\/jats:p>","DOI":"10.1017\/s0007114515000240","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T04:59:36Z","timestamp":1425445176000},"page":"859-864","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":38,"title":["The lower vitamin C plasma concentrations in elderly men compared with elderly women can partly be attributed to a volumetric dilution effect due to differences in fat-free 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