{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:01:22Z","timestamp":1790737282890,"version":"4.1.0"},"reference-count":59,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2015,12,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The purpose of this pilot study was to determine whether macronutrient content (low-fat\n                    <jats:italic>v<\/jats:italic>\n                    . high-fat diet) influences an indicator of advanced glycation end products (AGE),\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sup>\u03b5<\/jats:sup>\n                    carboxymethyl-lysine (CML), in the context of a 1-d, high-AGE diet. The effect of the diets on inflammatory markers was also assessed. A total of nineteen overweight and obese adults (nine men and ten women) without known disease were recruited to participate in a crossover challenge of a high-fat, high-AGE (HFHA) and low-fat, high-AGE (LFHA) diet. In each phase patients had fasting blood drawn, followed by consumption of a high-fat or low-fat breakfast test meal, then three postprandial blood draws at 1, 2 and 3 h after consuming the test meal. After consuming high-AGE meals for the remainder of the day, participants returned the next day for a follow-up analysis. A different pattern in the 3-h post-meal CML and soluble receptor for AGE response to the two diets was observed (\n                    <jats:italic>P<\/jats:italic>\n                    =0\u00b701 and 0\u00b705, respectively). No change in serum CML was observed following consumption of a LFHA breakfast (535 (25th\u201375th percentile 451\u2013790) to 495 (25th\u201375th percentile 391\u2013682) ng\/ml;\n                    <jats:italic>P<\/jats:italic>\n                    =0\u00b736), whereas a rise in CML occurred after the HFHA breakfast (463 (25th\u201375th percentile 428\u2013664) to 578 (25th\u201375th percentile 474\u2013865) ng\/ml;\n                    <jats:italic>P<\/jats:italic>\n                    =0\u00b705). High sensitivity C-reactive protein and high molecular weight adiponectin were not affected by either diet. These findings suggest that dietary CML may not be as important in influencing serum CML as other dietary factors. In addition, acute exposure to dietary CML may not influence inflammation in adults without diabetes or kidney disease. This is contrary to previous findings.\n                  <\/jats:p>","DOI":"10.1017\/s0007114515003487","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T04:04:54Z","timestamp":1442894694000},"page":"1797-1806","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":38,"title":["Contribution of dietary advanced glycation end products (AGE) to circulating AGE: role of dietary fat"],"prefix":"10.1017","volume":"114","author":[{"given":"Kathleen E.","family":"Davis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chandan","family":"Prasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parakat","family":"Vijayagopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanil","family":"Juma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverley","family":"Adams-Huet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victorine","family":"Imrhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"S0007114515003487_ref8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.28.17473"},{"key":"S0007114515003487_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2010.03.018"},{"key":"S0007114515003487_ref47","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4525"},{"key":"S0007114515003487_ref4","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq074"},{"key":"S0007114515003487_ref42","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.189480"},{"key":"S0007114515003487_ref56","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28737"},{"key":"S0007114515003487_ref51","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1433.030"},{"key":"S0007114515003487_ref59","doi-asserted-by":"publisher","DOI":"10.1093\/glycob\/cwi053"},{"key":"S0007114515003487_ref32","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.57"},{"key":"S0007114515003487_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.02.031"},{"key":"S0007114515003487_ref12","doi-asserted-by":"publisher","DOI":"10.2741\/3884"},{"key":"S0007114515003487_ref52","doi-asserted-by":"publisher","DOI":"10.1021\/ac2025706"},{"key":"S0007114515003487_ref33","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0091"},{"key":"S0007114515003487_ref6","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.080152"},{"key":"S0007114515003487_ref1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1093\/ajcn.81.2.341","article-title":"Origins and evolution of the Western diet: health implications for the 21st century","volume":"81","author":"Cordain","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"S0007114515003487_ref16","doi-asserted-by":"publisher","DOI":"10.1021\/jf103353e"},{"key":"S0007114515003487_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.04.012"},{"key":"S0007114515003487_ref50","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000190660.32863.cd"},{"key":"S0007114515003487_ref35","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0531"},{"key":"S0007114515003487_ref29","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1433.042"},{"key":"S0007114515003487_ref40","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0087"},{"key":"S0007114515003487_ref57","doi-asserted-by":"publisher","DOI":"10.1039\/c1fo10026b"},{"key":"S0007114515003487_ref39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5922.2011.00264.x"},{"key":"S0007114515003487_ref31","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0089"},{"key":"S0007114515003487_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.74"},{"key":"S0007114515003487_ref48","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1473"},{"key":"S0007114515003487_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2011.08.055"},{"key":"S0007114515003487_ref55","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2010.06.024"},{"key":"S0007114515003487_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2004.05.214"},{"key":"S0007114515003487_ref54","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1068"},{"key":"S0007114515003487_ref49","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2008.03.004"},{"key":"S0007114515003487_ref26","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.8.2314"},{"key":"S0007114515003487_ref37","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2011.139"},{"key":"S0007114515003487_ref41","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.12-40"},{"key":"S0007114515003487_ref46","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1528"},{"key":"S0007114515003487_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-8146(98)00244-1"},{"key":"S0007114515003487_ref38","doi-asserted-by":"publisher","DOI":"10.3945\/jn.111.143172"},{"key":"S0007114515003487_ref5","doi-asserted-by":"publisher","DOI":"10.1042\/CS20100501"},{"key":"S0007114515003487_ref58","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318921"},{"key":"S0007114515003487_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200600070"},{"key":"S0007114515003487_ref43","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-08-0510"},{"key":"S0007114515003487_ref36","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-013-0574-y"},{"key":"S0007114515003487_ref53","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0776-z"},{"key":"S0007114515003487_ref24","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/BF03402014","article-title":"Oxidative stress-inducing carbonyl compounds from common foods: novel mediators of cellular dysfunction","volume":"8","author":"Cai","year":"2002","journal-title":"Mol Med"},{"key":"S0007114515003487_ref10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.12.6474"},{"key":"S0007114515003487_ref34","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.1.223"},{"key":"S0007114515003487_ref28","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/ajcn\/85.5.1236","article-title":"Effects of low and high advanced glycation endproduct meals on macro and microvascular endothelial function and oxidative stress in patients with type 2 diabetes mellitus","volume":"85","author":"Negrean","year":"2007","journal-title":"Am J Clin Nutr"},{"key":"S0007114515003487_ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2004.02170.x"},{"key":"S0007114515003487_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2005.03.024"},{"key":"S0007114515003487_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.06.052"},{"key":"S0007114515003487_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2006.05.007"},{"key":"S0007114515003487_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200600304"},{"key":"S0007114515003487_ref25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.242407999"},{"key":"S0007114515003487_ref20","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1333.052"},{"key":"S0007114515003487_ref9","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/jn\/103.5.657","article-title":"Nutritional consequences of the Maillard reaction: amino acid availability from fructose-lysine and fructose-tryptophan in the rat","volume":"103","author":"Sgarbieri","year":"1973","journal-title":"J Nutr"},{"key":"S0007114515003487_ref7","doi-asserted-by":"publisher","DOI":"10.1038\/414813a"},{"key":"S0007114515003487_ref11","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-109033"},{"key":"S0007114515003487_ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-008-0071-4"},{"key":"S0007114515003487_ref30","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-0320"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114515003487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T20:54:46Z","timestamp":1555707286000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114515003487\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,22]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,12,14]]}},"alternative-id":["S0007114515003487"],"URL":"https:\/\/doi.org\/10.1017\/s0007114515003487","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,22]]},"assertion":[{"value":"Copyright \u00a9 The Authors 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}