{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:16:53Z","timestamp":1779081413492,"version":"3.51.4"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T00:00:00Z","timestamp":1444089600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2015,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was conducted to assess the effects of long-term Se administration on the regression and metabolic status of patients with cervical intraepithelial neoplasia grade 1 (CIN1). This randomised, double-blind, placebo-controlled trial was carried out among fifty-eight women diagnosed with CIN1. To diagnose CIN1, we used specific diagnostic procedures of biopsy, pathological diagnosis and colposcopy. Patients were randomly assigned to two groups to receive 200 \u03bcg Se supplements as Se yeast (<jats:italic>n<\/jats:italic> 28) or placebo (<jats:italic>n<\/jats:italic> 28) daily for 6 months. After 6 months of taking Se supplements, a greater percentage of women in the Se group had regressed CIN1 (88\u00b70 <jats:italic>v<\/jats:italic>. 56\u00b70 %; <jats:italic>P<\/jats:italic>=0\u00b701) compared with those in the placebo group. Long-term Se supplementation, compared with the placebo, resulted in significant decreases in fasting plasma glucose levels (\u22120\u00b737 (<jats:sc>sd<\/jats:sc> 0\u00b732) <jats:italic>v<\/jats:italic>. +0\u00b707 (<jats:sc>sd<\/jats:sc> 0\u00b763) mmol\/l; <jats:italic>P<\/jats:italic>=0\u00b7002), serum insulin levels (\u221228\u00b78 <jats:sc>(sd<\/jats:sc> 31\u00b72) <jats:italic>v<\/jats:italic>. +13\u00b72 <jats:sc>(sd<\/jats:sc> 40\u00b72) pmol\/l; <jats:italic>P<\/jats:italic>&lt;0\u00b7001), homeostatic model assessment of insulin resistance values (\u22121\u00b73 <jats:sc>(se<\/jats:sc> 1\u00b73) <jats:italic>v<\/jats:italic>. +0\u00b75 <jats:sc>(se<\/jats:sc> 1\u00b74); <jats:italic>P<\/jats:italic>&lt;0\u00b7001) and a significant elevation in quantitative insulin sensitivity check index (+0\u00b703 <jats:sc>(sd<\/jats:sc> 0\u00b703) <jats:italic>v<\/jats:italic>. \u22120\u00b701 <jats:sc>(sd<\/jats:sc> 0\u00b701); <jats:italic>P<\/jats:italic>&lt;0\u00b7001). In addition, patients who received Se supplements had significantly decreased serum TAG (\u22120\u00b714 <jats:sc>(sd<\/jats:sc> 0\u00b755) <jats:italic>v<\/jats:italic>. +0\u00b715 <jats:sc>(sd<\/jats:sc> 0\u00b738) mmol\/l; <jats:italic>P<\/jats:italic>=0\u00b702) and increased HDL-cholesterol levels (+0\u00b713 <jats:sc>(sd<\/jats:sc> 0\u00b721) <jats:italic>v<\/jats:italic>. \u22120\u00b701 <jats:sc>(sd<\/jats:sc> 0\u00b715) mmol\/l; <jats:italic>P<\/jats:italic>=0\u00b7003). In addition, compared with the placebo group, there were significant rises in plasma total antioxidant capacity (+186\u00b71 <jats:sc>(sd<\/jats:sc> 274\u00b76) <jats:italic>v<\/jats:italic>. +42\u00b78 <jats:sc>(sd<\/jats:sc> 180\u00b74) mmol\/l; <jats:italic>P<\/jats:italic>=0\u00b702) and GSH levels (+65\u00b70 <jats:sc>(sd<\/jats:sc> 359\u00b78) <jats:italic>v<\/jats:italic>. \u2212294\u00b72 <jats:sc>(sd<\/jats:sc> 581\u00b78) \u03bcmol\/l; <jats:italic>P<\/jats:italic>=0\u00b7007) and a significant decrease in malondialdehyde levels (\u22121\u00b75 <jats:sc>(sd<\/jats:sc> 2\u00b71) <jats:italic>v<\/jats:italic>. +0\u00b71 <jats:sc>(sd<\/jats:sc> 1\u00b74) \u03bcmol\/l; <jats:italic>P<\/jats:italic>=0\u00b7001) among those who took Se supplements. Overall, taking Se supplements among patients with CIN1 led to its regression and had beneficial effects on their metabolic profiles.<\/jats:p>","DOI":"10.1017\/s0007114515003852","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T05:48:41Z","timestamp":1444110521000},"page":"2039-2045","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":33,"title":["The favourable effects of long-term selenium supplementation on regression of cervical tissues and metabolic profiles of patients with cervical intraepithelial neoplasia: a randomised, double-blind, placebo-controlled trial"],"prefix":"10.1017","volume":"114","author":[{"given":"Maryam","family":"Karamali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepideh","family":"Nourgostar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraf","family":"Zamani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Vahedpoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zatollah","family":"Asemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,10,6]]},"reference":[{"key":"S0007114515003852_ref28","doi-asserted-by":"publisher","DOI":"10.5812\/numonthly.24781"},{"key":"S0007114515003852_ref13","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0840"},{"key":"S0007114515003852_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2015.04.014"},{"key":"S0007114515003852_ref12","first-page":"1167","article-title":"Clinical significance of human telomerase RNA gene (hTERC) amplification in cervical squamous cell lesions detected by fluorescence in situ hybridization","volume":"12","author":"Jin","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"key":"S0007114515003852_ref15","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0292"},{"key":"S0007114515003852_ref25","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(10)60038-1"},{"key":"S0007114515003852_ref1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327914nc4702_3"},{"key":"S0007114515003852_ref31","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2011.83"},{"key":"S0007114515003852_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12699"},{"key":"S0007114515003852_ref8","doi-asserted-by":"publisher","DOI":"10.1385\/BTER:94:2:113"},{"key":"S0007114515003852_ref4","first-page":"176","article-title":"A review of the natural history of cervical intraepithelial neoplasia","volume":"29","author":"Duggan","year":"2002","journal-title":"Gan To Kagaku Ryoho"},{"key":"S0007114515003852_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-0804-1"},{"key":"S0007114515003852_ref32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.4103\/0019-5154.39577","article-title":"Comparison of plasma malondialdehyde, glutathione, glutathione peroxidase, hydroxyproline and selenium levels in patients with vitiligo and healthy controls","volume":"53","author":"Ozturk","year":"2008","journal-title":"Indian J Dermatol"},{"key":"S0007114515003852_ref18","doi-asserted-by":"publisher","DOI":"10.1207\/S15327914NC401_12"},{"key":"S0007114515003852_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(97)00245-0"},{"key":"S0007114515003852_ref5","doi-asserted-by":"publisher","DOI":"10.1089\/aid.2010.0129"},{"key":"S0007114515003852_ref24","doi-asserted-by":"publisher","DOI":"10.1159\/000335470"},{"key":"S0007114515003852_ref9","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016328407610"},{"key":"S0007114515003852_ref19","first-page":"8","article-title":"Effect of antioxidants on markers of apoptosis in postoperative radiotherapy of cancer cervix","volume":"7","author":"Ismail","year":"2010","journal-title":"Gulf J Oncolog"},{"key":"S0007114515003852_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2008.05.012"},{"key":"S0007114515003852_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-013-9616-9"},{"key":"S0007114515003852_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.12.011"},{"key":"S0007114515003852_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/mutage\/get050"},{"key":"S0007114515003852_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(90)90131-2"},{"key":"S0007114515003852_ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2139-9"},{"key":"S0007114515003852_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)90079-5"},{"key":"S0007114515003852_ref29","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfs170"},{"key":"S0007114515003852_ref16","first-page":"581","article-title":"Plasma glutathione in health and in patients with malignant disease","volume":"105","author":"Beutler","year":"1985","journal-title":"J Lab Clin Med"},{"key":"S0007114515003852_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.02.017"},{"key":"S0007114515003852_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2006.02.027"},{"key":"S0007114515003852_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2003.12.008"},{"key":"S0007114515003852_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70103-7"},{"key":"S0007114515003852_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00004347-199304000-00018"}],"updated-by":[{"DOI":"10.1017\/s0007114521002014","type":"expression_of_concern","label":"Expression of concern","source":"retraction-watch","updated":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"record-id":"43703"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114515003852","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T00:56:00Z","timestamp":1555721760000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114515003852\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,6]]},"references-count":33,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2015,12,28]]}},"alternative-id":["S0007114515003852"],"URL":"https:\/\/doi.org\/10.1017\/s0007114515003852","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,6]]},"assertion":[{"value":"Copyright \u00a9 The Authors 2015\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}