{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:25:51Z","timestamp":1760865951577},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T00:00:00Z","timestamp":1446163200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2016,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Many studies have suggested that folate-related one-carbon metabolism-related nutrients may play a role in certain cancer risks, but few studies have assessed their associations with the risk for nasopharyngeal carcinoma (NPC). In this study, we investigated the association between four folate-related one-carbon metabolism-related nutrients (folate, vitamin B<jats:sub>6<\/jats:sub>, vitamin B<jats:sub>12<\/jats:sub> and methionine) and NPC risk in Chinese adults. A total of 600 patients newly diagnosed (within 3 months) with NPC were individually matched with 600 hospital-based controls by age, sex and household type (urban <jats:italic>v<\/jats:italic>. rural). Folate, vitamin B<jats:sub>6<\/jats:sub>, vitamin B<jats:sub>12<\/jats:sub> and methionine intakes were measured using a validated seventy-eight-item FFQ. A higher dietary folate or vitamin B<jats:sub>6<\/jats:sub> intake was associated with a lower NPC risk after adjusting for potential confounders. The adjusted OR of NPC for quartiles 2\u20134 (<jats:italic>v<\/jats:italic>. 1) were 0\u00b766 (95 % CI 0\u00b748, 0\u00b791), 0\u00b752 (95 % CI 0\u00b737, 0\u00b774) and 0\u00b734 (95 % CI 0\u00b723, 0\u00b750) (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>&lt;0\u00b7001) for folate and 0\u00b772 (95 % CI 0\u00b752, 1\u00b700), 0\u00b755 (95 % CI 0\u00b739, 0\u00b778) and 0\u00b744 (95 % CI 0\u00b730, 0\u00b763) (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>&lt;0\u00b7001) for vitamin B<jats:sub>6<\/jats:sub>. No significant association with NPC risk was observed for dietary vitamin B<jats:sub>12<\/jats:sub> or methionine intake. The risk for NPC with dietary folate intake was more evident in the participants who were not exposed to toxic substances than in those who were exposed (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>=0\u00b7014). This study suggests that dietary folate and vitamin B<jats:sub>6<\/jats:sub> may be protective for NPC in a high-risk population.<\/jats:p>","DOI":"10.1017\/s0007114515004146","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T01:32:51Z","timestamp":1446168771000},"page":"121-128","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":19,"title":["Folate, vitamin B<sub>6<\/sub>, vitamin B<sub>12<\/sub> and methionine intakes and risk for nasopharyngeal carcinoma in Chinese adults: a matched case\u2013control 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