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The association between these nutrients and oesophageal adenocarcinoma \u2013 a tumour with increasing incidence in developed countries and poor survival rates \u2013 has yet to be explored. The aim of this investigation was to explore the association between Mg intake and related nutrients and risk of oesophageal adenocarcinoma and its precursor conditions, Barrett\u2019s oesophagus and reflux oesophagitis. This analysis included cases of oesophageal adenocarcinoma (<jats:italic>n<\/jats:italic>218), Barrett\u2019s oesophagus (<jats:italic>n<\/jats:italic>212), reflux oesophagitis (<jats:italic>n<\/jats:italic>208) and population-based controls (<jats:italic>n<\/jats:italic>252) recruited between 2002 and 2005 throughout the island of Ireland. All the subjects completed a 101-item FFQ. Unconditional logistic regression analysis was applied to determine odds of disease according to dietary intakes of Mg, Ca and Ca:Mg ratio. After adjustment for potential confounders, individuals consuming the highest amounts of Mg from foods had significant reductions in the odds of reflux oesophagitis (OR 0\u00b731; 95 % CI 0\u00b711, 0\u00b787) and Barrett\u2019s oesophagus (OR 0\u00b729; 95 % CI 0\u00b712, 0\u00b771) compared with individuals consuming the lowest amounts of Mg. The protective effect of Mg was more apparent in the context of a low Ca:Mg intake ratio. No significant associations were observed for Mg intake and oesophageal adenocarcinoma risk (OR 0\u00b777; 95 % CI 0\u00b730, 1\u00b799 comparing the highest and the lowest tertiles of consumption). In conclusion, dietary Mg intakes were inversely associated with reflux oesophagitis and Barrett\u2019s oesophagus risk in this Irish population.<\/jats:p>","DOI":"10.1017\/s0007114515004444","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T09:18:01Z","timestamp":1447406281000},"page":"342-350","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":37,"title":["Dietary magnesium, calcium:magnesium ratio and risk of reflux oesophagitis, Barrett\u2019s oesophagus and oesophageal adenocarcinoma: a population-based case\u2013control study"],"prefix":"10.1017","volume":"115","author":[{"given":"Qi","family":"Dai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie M.","family":"Cantwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam 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