{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T18:26:36Z","timestamp":1794507996952,"version":"4.9.1"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T00:00:00Z","timestamp":1447977600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2016,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effect of protein intake on growth velocity in infancy may be mediated by insulin-like growth factor-1 (IGF-1). This study aimed to determine the effects of formulae containing 1\u00b78 (F1\u00b78) or 2\u00b77 g (F2\u00b77) protein\/418\u00b74 kJ (100 kcal) on IGF-1 concentrations and growth. Healthy term infants were randomly assigned to receive F1\u00b78 (\n                    <jats:italic>n<\/jats:italic>\n                    74) or F2\u00b77 (\n                    <jats:italic>n<\/jats:italic>\n                    80) exclusively for the first 4 months of life. A group of breast-fed infants (\n                    <jats:italic>n<\/jats:italic>\n                    84) was followed-up simultaneously (reference). Growth and body composition were measured at 0\u00b75, 4, 6, 12, 36, 48 and 60 months of life. The IGF-1 concentrations at 4 months (primary outcome) were similar in the F1\u00b78 (67\u00b71 (\n                    <jats:sc>sd<\/jats:sc>\n                    20\u00b78) ng\/l;\n                    <jats:italic>n<\/jats:italic>\n                    70) and F2\u00b77 (71\u00b72 (\n                    <jats:sc>sd<\/jats:sc>\n                    27\u00b75) ng\/l;\n                    <jats:italic>n<\/jats:italic>\n                    73) groups (\n                    <jats:italic>P<\/jats:italic>\n                    =0\u00b752). Both formula groups had higher IGF-1 concentrations than the breast-fed group at 4 and 9 months of age (\n                    <jats:italic>P<\/jats:italic>\n                    \u22640\u00b70001). During the first 60 months of life, anthropometric parameters in the F1\u00b78 group were lower compared with the F2\u00b77 group, and the differences were significant for head circumference from 2 to 60 months, body weight at 4 and 6 months and length at 9, 12 and 36 months of age. There were no significant differences in body composition between these two groups at any age. We conclude that, in formula-fed infants, although increased protein intake did not affect the IGF-1 concentration during the first 12 months of life, it did affect length and head circumference growth, suggesting that factors other than IGF-1 could play roles in determining growth velocity.\n                  <\/jats:p>","DOI":"10.1017\/s0007114515004456","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T04:26:09Z","timestamp":1447993569000},"page":"271-284","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":55,"title":["Effect of dietary protein on plasma insulin-like growth factor-1, growth, and body composition in healthy term infants: a randomised, double-blind, controlled trial (Early Protein and Obesity in Childhood (EPOCH) study)"],"prefix":"10.1017","volume":"115","author":[{"given":"Guy","family":"Putet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Labaune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Mace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Steenhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Grathwohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronique","family":"Raverot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Morel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Charles","family":"Picaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,11,20]]},"reference":[{"key":"S0007114515004456_ref38","doi-asserted-by":"publisher","DOI":"10.1159\/000367998"},{"key":"S0007114515004456_ref40","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.2527\/1997.75102739x","volume":"75","year":"1997","journal-title":"J 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