{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T16:22:37Z","timestamp":1776702157391,"version":"3.51.2"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T00:00:00Z","timestamp":1456876800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2016,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the effect of maternal vitamin E supplementation on the <jats:italic>\u03b1<\/jats:italic>-tocopherol concentrations of colostrum, transitional milk and mature milk of women who had given birth prematurely. This longitudinal randomised-controlled trial divided eighty-nine women into two groups: a control group and a supplemented group. Blood and breast milk were collected from all the participants after delivery. Next, each woman in the supplemented group received 400 IU of RRR-<jats:italic>\u03b1<\/jats:italic>-tocopheryl acetate. Further breast milk samples were collected 24 h after the first collection, as well as 7 and 30 d after delivery. <jats:italic>\u03b1<\/jats:italic>-Tocopherol concentrations were determined by HPLC. The baseline <jats:italic>\u03b1<\/jats:italic>-tocopherol concentrations in the maternal serum of the two groups were similar: 1159\u00b78 (<jats:sc>sd<\/jats:sc> 292\u00b74) \u03bcg\/dl (27\u00b70 (<jats:sc>SD<\/jats:sc> 6\u00b78) \u03bcmol\/l) for the control group and 1128\u00b73 (<jats:sc>sd<\/jats:sc> 407\u00b72) \u03bcg\/dl (26\u00b72 (<jats:sc>SD<\/jats:sc> 9\u00b75) \u03bcmol\/l) for the supplemented group. None of the women was vitamin E deficient. Breast milk <jats:italic>\u03b1<\/jats:italic>-tocopherol concentrations increased by 60 % 24 h after supplementation in the intervention group and did not increase at all in the control group. <jats:italic>\u03b1<\/jats:italic>-Tocopherol concentration of the transitional milk in the supplemented group was 35 % higher compared with the control group. <jats:italic>\u03b1<\/jats:italic>-Tocopherol concentrations of the mature milk in both groups were similar. Maternal supplementation with 400 IU of RRR-<jats:italic>\u03b1<\/jats:italic>-tocopherol increased the vitamin E concentrations of the colostrum and transitional milk, but not of the mature milk. This study presents relevant information for the design of strategies to prevent and combat vitamin E deficiency in the risk group of preterm infants.<\/jats:p>","DOI":"10.1017\/s0007114516000477","type":"journal-article","created":{"date-parts":[[2016,3,2]],"date-time":"2016-03-02T11:23:23Z","timestamp":1456917803000},"page":"1424-1430","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":16,"title":["<i>\u03b1<\/i>-Tocopherol in breast milk of women with preterm delivery after a single postpartum oral dose of vitamin E"],"prefix":"10.1017","volume":"115","author":[{"given":"Jeane Franco","family":"Pires Medeiros","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla Danielly da Silva","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayara Santa 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