{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:50:39Z","timestamp":1792173039659,"version":"4.4.0"},"reference-count":54,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T00:00:00Z","timestamp":1461801600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2016,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The International Clearinghouse for Birth Defects, Surveillance and Research reports a rise in the prevalence rate of spina bifida in Japan. We determined first-trimester folate status of Hokkaido women and identified potential predictors. Participants were 15 266 pregnant women of the Hokkaido Study on Environment and Children\u2019s Health Cohort. Data were extracted from self-reported questionnaires and biochemical assay results. Demographic determinants of low folate status were younger maternal age (adjusted OR (AOR) 1\u00b748; 95 % CI 1\u00b732, 1\u00b766), lower educational level (AOR 1\u00b727; 95 % CI 1\u00b717, 1\u00b739) and lower annual income (AOR 1\u00b711; 95 % CI 1\u00b701, 1\u00b722). Plasma cotinine concentrations of 1\u00b719\u201365\u00b721 nmol\/l increased the risk of low folate status (AOR 1\u00b720; 95 % CI 1\u00b710, 1\u00b731) and concentrations &gt;65\u00b721 nmol\/l further increased the risk (AOR 1\u00b791; 95 % CI 1\u00b770, 2\u00b714). The most favourable predictor was use of folic acid (FA) supplements (AOR 0\u00b719; 95 % CI 0\u00b717, 0\u00b722). Certain socio-demographic factors influence folate status among pregnant Japanese women. Modifiable negative and positive predictors were active and passive tobacco smoking and use of FA supplements. Avoiding both active and passive tobacco smoking and using FA supplements could improve the folate status of Japanese women.<\/jats:p>","DOI":"10.1017\/s0007114516001628","type":"journal-article","created":{"date-parts":[[2016,4,28]],"date-time":"2016-04-28T17:00:46Z","timestamp":1461862846000},"page":"2227-2235","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["Predictors of folate status among pregnant Japanese women: the Hokkaido Study on Environment and Children\u2019s Health, 2002\u20132012"],"prefix":"10.1017","volume":"115","author":[{"given":"Thamar A.","family":"Yila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsuko","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiko","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Miyashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumiko","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamiko","family":"Ikeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Yoshioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumitaka","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houman","family":"Goudarzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Baba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titilola","family":"Braimoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisanori","family":"Minakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Sengoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Kishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,4,28]]},"reference":[{"key":"S0007114516001628_ref52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2005.00294.x"},{"key":"S0007114516001628_ref50","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.12.924"},{"key":"S0007114516001628_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12199-013-0357-3"},{"key":"S0007114516001628_ref2","first-page":"1","article-title":"Surveillance for anencephaly and spina bifida and the impact of prenatal diagnosis \u2013 United States, 1985\u20131994","volume":"44","author":"Cragan","year":"1995","journal-title":"MMWR CDC Surveill Summ"},{"key":"S0007114516001628_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-6405.2012.00910.x"},{"key":"S0007114516001628_ref26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602212"},{"key":"S0007114516001628_ref40","year":"2000"},{"key":"S0007114516001628_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1341-8076.2005.00265.x"},{"key":"S0007114516001628_ref29","doi-asserted-by":"publisher","DOI":"10.1136\/jech.54.1.17"},{"key":"S0007114516001628_ref31","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2009.137513"},{"key":"#cr-split#-S0007114516001628_ref3.1","unstructured":"1. Flour Fortification Initiative (2011) Fifteen years of fortifying with folic acid reduces birth defects"},{"key":"#cr-split#-S0007114516001628_ref3.2","unstructured":"2. averts healthcare expenses. http:\/\/www.ffinetwork.org\/about\/stay_informed\/publications\/documents\/FolicAcidBackground.pdf (accessed February 2016)."},{"key":"S0007114516001628_ref19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1093\/ajcn\/87.2.362","article-title":"Vitamin status in morbidly obese patients: a cross-sectional study","volume":"87","author":"Aasheim","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"S0007114516001628_ref41","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-003-0778-1"},{"key":"S0007114516001628_ref18","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-11-34"},{"key":"S0007114516001628_ref53","doi-asserted-by":"publisher","DOI":"10.2217\/14622416.8.1.5"},{"key":"S0007114516001628_ref35","doi-asserted-by":"publisher","DOI":"10.1186\/1617-9625-4-8"},{"key":"S0007114516001628_ref14","first-page":"235","article-title":"Determination of vitamin B12 and folate by ADVIA Centaur","volume":"29","author":"Sujaku","year":"2006","journal-title":"J Anal Bio-Sci"},{"key":"S0007114516001628_ref25","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1093\/jn\/133.11.3630","article-title":"Geographical, seasonal and gender differences in folate status among Chinese adults","volume":"133","author":"Hao","year":"2003","journal-title":"J Nutr"},{"key":"S0007114516001628_ref9","first-page":"5","article-title":"Dietary folate intake and serum folate status in Japanese women of childbearing age","volume":"32","author":"Ihara","year":"2009","journal-title":"J Anal Bio-Sci"},{"key":"S0007114516001628_ref38","first-page":"537","article-title":"Folic acid reduces the risk of neural tube defects: awareness and folate intake among pregnant women in 2006","volume":"54","author":"Kondo","year":"2008","journal-title":"Hinyokika Kiyo"},{"key":"S0007114516001628_ref32","doi-asserted-by":"publisher","DOI":"10.1080\/1462220031000094330"},{"key":"S0007114516001628_ref48","doi-asserted-by":"crossref","first-page":"2367S","DOI":"10.1093\/jn\/132.8.2367S","article-title":"Metabolic interactions of alcohol and folate","volume":"132","author":"Halsted","year":"2002","journal-title":"J Nutr"},{"key":"S0007114516001628_ref43","first-page":"341","article-title":"Dietary and blood folate status of Malaysian women of childbearing age","volume":"15","author":"Khor","year":"2006","journal-title":"Asia Pac J Clin Nutr"},{"key":"S0007114516001628_ref30","doi-asserted-by":"publisher","DOI":"10.1006\/pmed.2002.1024"},{"key":"S0007114516001628_ref39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01358.x"},{"key":"S0007114516001628_ref37","doi-asserted-by":"publisher","DOI":"10.1378\/chest.06-2179"},{"key":"S0007114516001628_ref10","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20110039"},{"key":"S0007114516001628_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91560-H"},{"key":"S0007114516001628_ref51","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041211"},{"key":"S0007114516001628_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2006.04.051"},{"key":"S0007114516001628_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2012.111"},{"key":"S0007114516001628_ref33","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2004.10719380"},{"key":"S0007114516001628_ref49","unstructured":"International Center for Alcohol Policies (ICAP) (1995) ICAP Blue Book 10. Drinking and pregnancy. http:\/\/www.icap.org\/PolicyTools\/ICAPBlueBook\/BlueBookModules\/10DrinkingandPregnancy\/tabid\/171\/Default.aspx (accessed February 2016)."},{"key":"S0007114516001628_ref47","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1601191"},{"key":"S0007114516001628_ref17","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.94.9.1592"},{"key":"S0007114516001628_ref24","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20051590"},{"key":"S0007114516001628_ref36","doi-asserted-by":"publisher","DOI":"10.1159\/000075139"},{"key":"S0007114516001628_ref46","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der078"},{"key":"S0007114516001628_ref8","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1447-0756.2008.00821.x","article-title":"Dietary folate intake, use of folate supplements, lifestyle factors, and serum folate levels among pregnant women in Tokyo, Japan","volume":"34","author":"Matsuzaki","year":"2008","journal-title":"J Obstet Gynaecol Res"},{"key":"S0007114516001628_ref20","doi-asserted-by":"publisher","DOI":"10.3390\/nu5020565"},{"key":"S0007114516001628_ref23","doi-asserted-by":"publisher","DOI":"10.3945\/jn.112.169987"},{"key":"S0007114516001628_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2011.10.019"},{"key":"S0007114516001628_ref28","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2009.103"},{"key":"S0007114516001628_ref15","first-page":"103","volume-title":"Laboratory Tests for the Assessment of Nutritional Status","author":"Sauberlich","year":"1999"},{"key":"S0007114516001628_ref45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-277X.2008.00936.x"},{"key":"S0007114516001628_ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1740-8709.2008.00172.x"},{"key":"S0007114516001628_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.02163.x"},{"key":"S0007114516001628_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq071"},{"key":"S0007114516001628_ref34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01154.x"},{"key":"S0007114516001628_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2006.02.003"},{"key":"S0007114516001628_ref7","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1602497"},{"key":"S0007114516001628_ref44","first-page":"269","article-title":"Red cell folate and predicted neural tube defect rate in three Asian cities","volume":"16","author":"Green","year":"2007","journal-title":"Asia Pac J Clin Nutr"},{"key":"S0007114516001628_ref13","volume-title":"Diagnostics B Package Insert: ADVIA Centaur Assay Manual","year":"1998"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114516001628","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,16]],"date-time":"2024-06-16T02:17:52Z","timestamp":1718504272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114516001628\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,28]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2016,6,28]]}},"alternative-id":["S0007114516001628"],"URL":"https:\/\/doi.org\/10.1017\/s0007114516001628","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,28]]},"assertion":[{"value":"Copyright \u00a9 The Authors 2016\u00a0","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}