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We investigated the changes following addition of inulin oligofructose (IO) in the food of rats fed either a corn starch (C) diet or a high-carbohydrate, high-fat (H) diet as a model of diet-induced metabolic syndrome. IO did not affect food intake, but reduced body weight gain by 5\u00b73 and 12\u00b73 % in corn starch+inulin oligofructose (CIO) and high-carbohydrate, high-fat with inulin oligofructose (HIO) rats, respectively. IO reduced plasma concentrations of free fatty acids by 26\u00b72 % and TAG by 75\u00b78 % in HIO rats. IO increased faecal output by 93\u00b72 %, faecal lipid excretion by 37\u00b79 % and weight of caecum by 23\u00b74 % and colon by 41\u00b75 % in HIO rats. IO improved ileal morphology by reducing inflammation and improving the density of crypt cells in HIO rats. IO attenuated H diet-induced increases in abdominal fat pads (C 275 (<jats:sc>sem<\/jats:sc>19), CIO 264 (<jats:sc>sem<\/jats:sc>40), H 688 (<jats:sc>sem<\/jats:sc>55), HIO 419 (<jats:sc>sem<\/jats:sc>32) mg\/mm tibial length), fasting blood glucose concentrations (C 4\u00b75 (<jats:sc>sem<\/jats:sc>0\u00b71), CIO 4\u00b72 (<jats:sc>sem<\/jats:sc>0\u00b71), H 5\u00b72 (<jats:sc>sem<\/jats:sc>0\u00b71), HIO 4\u00b73 (<jats:sc>sem<\/jats:sc>0\u00b71) mmol\/l), systolic blood pressure (C 124 (<jats:sc>sem<\/jats:sc>2), CIO 118 (<jats:sc>sem<\/jats:sc>2), H 152 (<jats:sc>sem<\/jats:sc>2), HIO 123 (<jats:sc>sem<\/jats:sc>3) mmHg), left ventricular diastolic stiffness (C 22\u00b79 (<jats:sc>sem<\/jats:sc>0\u00b76), CIO 22\u00b79 (<jats:sc>sem<\/jats:sc>0\u00b75), H 27\u00b78 (<jats:sc>sem<\/jats:sc>0\u00b75), HIO 22\u00b76 (<jats:sc>sem<\/jats:sc>1\u00b72)) and plasma alanine transaminase (C 29\u00b76 (<jats:sc>sem<\/jats:sc>2\u00b78), CIO 32\u00b71 (<jats:sc>sem<\/jats:sc>3\u00b70), H 43\u00b79 (<jats:sc>sem<\/jats:sc>2\u00b76), HIO 33\u00b76 (<jats:sc>sem<\/jats:sc>2\u00b70) U\/l). IO attenuated H-induced increases in inflammatory cell infiltration in the heart and liver, lipid droplets in the liver and plasma lipids as well as impaired glucose and insulin tolerance. These results suggest that increasing soluble fibre intake with IO improves signs of the metabolic syndrome by decreasing gastrointestinal carbohydrate and lipid uptake.<\/jats:p>","DOI":"10.1017\/s0007114516003627","type":"journal-article","created":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T13:42:41Z","timestamp":1478094161000},"page":"1502-1511","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":58,"title":["Inulin oligofructose attenuates metabolic syndrome in high-carbohydrate, high-fat diet-fed rats"],"prefix":"10.1017","volume":"116","author":[{"given":"Senthil A.","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh C.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2016,11,2]]},"reference":[{"key":"S0007114516003627_ref11","doi-asserted-by":"publisher","DOI":"10.1079\/BJN20041225"},{"key":"S0007114516003627_ref67","doi-asserted-by":"publisher","DOI":"10.3109\/08037051.2014.940710"},{"key":"S0007114516003627_ref28","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802785"},{"key":"S0007114516003627_ref66","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101322"},{"key":"S0007114516003627_ref61","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.09.009"},{"key":"S0007114516003627_ref44","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.11.2585S"},{"key":"S0007114516003627_ref63","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181a2bcd6"},{"key":"S0007114516003627_ref5","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-13-34"},{"key":"S0007114516003627_ref52","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/602832"},{"key":"S0007114516003627_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.11.2493S"},{"key":"S0007114516003627_ref48","doi-asserted-by":"publisher","DOI":"10.1038\/ajgsup.2012.5"},{"key":"S0007114516003627_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-012-0846-2"},{"key":"S0007114516003627_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jada.2010.03.025"},{"key":"S0007114516003627_ref60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200319246"},{"key":"S0007114516003627_ref23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"S0007114516003627_ref26","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4512"},{"key":"S0007114516003627_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.07.007"},{"key":"S0007114516003627_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-003-0390-x"},{"key":"S0007114516003627_ref20","doi-asserted-by":"publisher","DOI":"10.3390\/md13020788"},{"key":"S0007114516003627_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2012.07.014"},{"key":"S0007114516003627_ref25","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19910062"},{"key":"S0007114516003627_ref55","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2008.165886"},{"key":"S0007114516003627_ref31","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.1.132"},{"key":"S0007114516003627_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.11.011"},{"key":"S0007114516003627_ref29","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2011.136"},{"key":"S0007114516003627_ref70","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.171"},{"key":"S0007114516003627_ref58","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90123-7"},{"key":"S0007114516003627_ref37","doi-asserted-by":"publisher","DOI":"10.1007\/BF02708379"},{"key":"S0007114516003627_ref36","doi-asserted-by":"publisher","DOI":"10.3390\/nu5041417"},{"key":"S0007114516003627_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510000966"},{"key":"S0007114516003627_ref41","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nutr.18.1.117"},{"key":"S0007114516003627_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2012.12.008"},{"key":"S0007114516003627_ref1","unstructured":"Granado-Lorencio F & Hern\u00e1ndez-Alvarez E (2016) Functional foods and health effects: a nutritional biochemistry perspective. 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