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There is some evidence to suggest that polyphenol-rich foods can play an important role in delaying the onset or halting the progression of age-related health disorders such as CVD and Alzheimer\u2019s disease and to improve cognitive function. In the present study, an acute, placebo-controlled, double-blinded, cross-over, randomised Latin-square design study with a washout period of at least 14 d was conducted on twenty-seven, middle-aged (defined as 45\u201360 years) volunteers. Participants received either a 60 ml dose of Montmorency tart cherry concentrate (MC), which contained 68\u00b70 (<jats:sc>sd<\/jats:sc> 0\u00b726) mg cyanidin-3-glucoside\/l, 160\u00b775 (<jats:sc>sd<\/jats:sc> 0\u00b755) mean gallic acid equivalent\/l and 0\u00b759 (<jats:sc>sd<\/jats:sc> 0\u00b702) mean Trolox equivalent\/l, respectively, or a placebo. Cerebrovascular responses, cognitive performance and blood pressure were assessed at baseline and 1, 2, 3 and 5 h following consumption. There were significant differences in concentrations of total Hb and oxygenated Hb during the task period 1 h after MC consumption (<jats:italic>P<\/jats:italic>\u22640\u00b705). Furthermore, MC consumption significantly lowered systolic blood pressure (<jats:italic>P<\/jats:italic>\u22640\u00b705) over a period of 3 h, with peak reductions of 6\u00b12 mmHg at 1 h after MC consumption relative to the placebo. Cognitive function and mood were not affected. These results show that a single dose of MC concentrate can modulate certain variables of vascular function; however, this does not translate to improvements in cognition or mood.<\/jats:p>","DOI":"10.1017\/s0007114516004177","type":"journal-article","created":{"date-parts":[[2016,12,18]],"date-time":"2016-12-18T22:00:05Z","timestamp":1482098405000},"page":"1935-1944","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":53,"title":["Montmorency Tart cherries (<i>Prunus cerasus<\/i> L.) modulate vascular function acutely, in the absence of improvement in cognitive performance"],"prefix":"10.1017","volume":"116","author":[{"given":"K. M.","family":"Keane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. F.","family":"Haskell-Ramsay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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