{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:34:43Z","timestamp":1775176483941,"version":"3.50.1"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T00:00:00Z","timestamp":1482192000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2016,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Supplementation with<jats:italic>n<\/jats:italic>-3 fatty acids may improve long-term outcomes of renal transplant recipients (RTR). Recent evidence suggests that EPA and DHA have different outcomes compared with<jats:italic>\u03b1<\/jats:italic>-linolenic acid (ALA). We examined the prospective associations of EPA\u2013DHA and ALA intakes with graft failure and all-cause mortality in 637 RTR. During 3\u00b71 years (interquartile range 2\u00b77, 3\u00b78) of follow-up, forty-one developed graft failure and sixty-seven died. In age- and sex-adjusted analyses, EPA\u2013DHA and ALA intakes were not associated with graft failure. EPA\u2013DHA intake was not significantly associated with mortality (hazard ratio (HR) 0\u00b779; 95% CI 0\u00b754, 1\u00b715 per 0\u00b71 energy% difference). ALA intake was significantly associated with mortality (HR 1\u00b717; 95% CI 1\u00b704, 1\u00b731 per 0\u00b71 energy% difference). This association remained following adjustments for BMI, proteinuria and intakes of fat, carbohydrate and protein. RTR in the highest tertile of ALA intake exhibited about 2-fold higher mortality risk (HR 2\u00b721; 95% CI 1\u00b723, 3\u00b797) compared with the lowest tertile. In conclusion, ALA intake may be associated with increased mortality in RTR. Future RCT are needed to confirm these results.<\/jats:p>","DOI":"10.1017\/s0007114516004207","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T09:54:49Z","timestamp":1482227689000},"page":"2066-2073","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Intake of<i>n<\/i>-3 fatty acids and long-term outcome in renal transplant recipients: a<i>post hoc<\/i>analysis of a prospective cohort study"],"prefix":"10.1017","volume":"116","author":[{"given":"Ilse G.","family":"Pranger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eke G.","family":"Gruppen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Else","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabita S.","family":"Soedamah-Muthu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerjan","family":"Navis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rijk O. 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