{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T15:27:02Z","timestamp":1774020422983,"version":"3.50.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T00:00:00Z","timestamp":1486339200000},"content-version":"unspecified","delay-in-days":9,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2017,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>DHA from diet or endogenous synthesis has been proposed to affect infant development, however, results are inconclusive. In this study, we aim to verify previously observed fatty acid desaturase gene cluster (<jats:italic>FADS<\/jats:italic>) SNP-specific associations with erythrocyte DHA status in 9-month-old children and sex-specific association with developmental outcomes. The study was performed in 166 children (55 % boys) of obese mothers. Erythrocyte fatty acid composition was analysed in blood-samples obtained at 9 months of age, and developmental outcomes assessed by the Ages and Stages Questionnaire at 3 years. Erythrocyte DHA level ranged from 4\u00b74 to 9\u00b79 % of fatty acids, but did not show any association with<jats:italic>FADS<\/jats:italic>SNP or other potential determinants. Regression analysis showed associations between erythrocyte DHA and scores for personal\u2013social skills (<jats:italic>\u03b2<\/jats:italic>1\u00b78 (95 % CI 0\u00b73, 3\u00b73),<jats:italic>P<\/jats:italic>=0\u00b7019) and problem solving (<jats:italic>\u03b2<\/jats:italic>3\u00b74 (95 % CI 1\u00b72, 5\u00b76),<jats:italic>P<\/jats:italic>=0\u00b7003). A tendency was observed for an association in opposite direction between minor alleles (G-variant) of rs1535 and rs174575 and personal\u2013social skills (<jats:italic>P<\/jats:italic>=0\u00b7062 and 0\u00b7068, respectively), which became significant when the SNP were combined based on their previously observed effect on erythrocyte DHA at 9 months of age (<jats:italic>\u03b2<\/jats:italic>2\u00b76 (95 % CI 0\u00b701, 5\u00b71),<jats:italic>P<\/jats:italic>=0\u00b7011). Sex\u2013SNP interaction was indicated for rs174575 genotype on fine motor scores (<jats:italic>P<\/jats:italic>=0\u00b7016), due to higher scores among minor allele carrying girls (<jats:italic>P<\/jats:italic>=0\u00b7043), whereas no effect was seen among boys. In conclusion, DHA-increasing<jats:italic>FADS<\/jats:italic>SNP and erythrocyte DHA status were consistently associated with improved personal\u2013social skills in this small cohort of children of obese mothers irrespective of sex, but the sample was too small to verify potential sex-specific effects.<\/jats:p>","DOI":"10.1017\/s0007114516004645","type":"journal-article","created":{"date-parts":[[2017,2,6]],"date-time":"2017-02-06T09:03:33Z","timestamp":1486371813000},"page":"278-286","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":14,"title":["A study of associations between early DHA status and fatty acid desaturase (<i>FADS<\/i>) SNP and developmental outcomes in children of obese mothers"],"prefix":"10.1017","volume":"117","author":[{"given":"Karina R.","family":"Andersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurine B. 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