{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:17:49Z","timestamp":1780467469671,"version":"3.54.1"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T00:00:00Z","timestamp":1490572800000},"content-version":"unspecified","delay-in-days":13,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2017,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum uric acid (SUA), a causative agent for gout among others, is affected by both genetic and dietary factors, perhaps differentially by sex. We evaluated cross-sectional (SUA<jats:sub>base<\/jats:sub>) and longitudinal (SUA<jats:sub>rate<\/jats:sub>) associations of SUA with a genetic risk score (GRS), diet and sex. We then tested the interactive effect of GRS, diet and sex on SUA. Longitudinal data on 766 African-American urban adults participating in the Healthy Aging in Neighborhood of Diversity across the Lifespan study were used. In all, three GRS for SUA were created from known SUA-associated SNP (GRS<jats:sub>base<\/jats:sub> (<jats:italic>n<\/jats:italic> 12 SNP), GRS<jats:sub>rate<\/jats:sub> (<jats:italic>n<\/jats:italic> 3 SNP) and GRS<jats:sub>total<\/jats:sub> (<jats:italic>n<\/jats:italic> 15 SNP)). Dietary factors included added sugar, total alcohol, red meat, total fish, legumes, dairy products, caffeine and vitamin C. Mixed-effects linear regression models were conducted. SUA<jats:sub>base<\/jats:sub> was higher among men compared with that among women, and increased with GRS<jats:sub>total<\/jats:sub> tertiles. SUA<jats:sub>rate<\/jats:sub> was positively associated with legume intake in women (<jats:italic>\u03b3<\/jats:italic>=+0\u00b714; 95 % CI +0\u00b706, +0\u00b722, <jats:italic>P<\/jats:italic>=0\u00b7001) and inversely related to dairy product intake in both sexes combined (<jats:italic>\u03b3<\/jats:italic>=\u22120\u00b7042; 95 % CI \u22120\u00b7075, \u22120\u00b7009), <jats:italic>P<\/jats:italic>=0\u00b7010). SUA<jats:sub>base<\/jats:sub> was directly linked to alcohol consumption among women (<jats:italic>\u03b3<\/jats:italic>=+0\u00b7154; 95 % CI +0\u00b7046, +0\u00b7262, <jats:italic>P<\/jats:italic>=0\u00b7005). GRS<jats:sub>rate<\/jats:sub> was linearly related to SUA<jats:sub>rate<\/jats:sub> only among men. Legume consumption was also positively associated with SUA<jats:sub>rate<\/jats:sub> within the GRS<jats:sub>total<\/jats:sub>\u2019s lowest tertile. Among women, a synergistic interaction was observed between GRS<jats:sub>rate<\/jats:sub> and red meat intake in association with SUA<jats:sub>rate<\/jats:sub>. Among men, a synergistic interaction between low vitamin C and genetic risk was found. In sum, sex\u2013diet, sex\u2013gene and gene\u2013diet interactions were detected in determining SUA. Further similar studies are needed to replicate our findings.<\/jats:p>","DOI":"10.1017\/s0007114517000411","type":"journal-article","created":{"date-parts":[[2017,3,27]],"date-time":"2017-03-27T05:15:24Z","timestamp":1490591724000},"page":"686-697","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":20,"title":["Genetic risk scores, sex and dietary factors interact to alter serum uric acid trajectory among African-American urban adults"],"prefix":"10.1017","volume":"117","author":[{"given":"May A.","family":"Beydoun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose-Atilio","family":"Canas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie T.","family":"Fanelli-Kuczmarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman 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