{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:50:06Z","timestamp":1776988206974,"version":"3.51.4"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T00:00:00Z","timestamp":1491436800000},"content-version":"unspecified","delay-in-days":9,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2017,3,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In a longitudinal study including 642 healthy 8\u201311-year-old Danish children, we investigated associations between vitamin D dependent SNP and serum 25-hydroxyvitamin D (25(OH)D) concentrations across a school year (August\u2013June). Serum 25(OH)D was measured three times for every child, which approximated measurements in three seasons (autumn, winter, spring). Dietary and supplement intake, physical activity, BMI and parathyroid hormone were likewise measured at each time point. In all, eleven SNP in four vitamin D-related genes: Cytochrome P450 subfamily IIR1 (<jats:italic>CYP2R1<\/jats:italic>); 7-dehydrocholesterol reductase\/nicotinamide adenine dinucleotide synthetase-1(<jats:italic>DHCR7\/NADSYN1<\/jats:italic>); group-specific complement (<jats:italic>GC<\/jats:italic>); and vitamin D receptor were genotyped. We found minor alleles of <jats:italic>CYP2R1<\/jats:italic> rs10500804, and of <jats:italic>GC<\/jats:italic> rs4588 and rs7041 to be associated with lower serum 25(OH)D concentrations across the three seasons (all <jats:italic>P<\/jats:italic>&lt;0\u00b701), with estimated 25(OH)D differences of \u22125\u00b78 to \u221210\u00b76 nmol\/l from major to minor alleles homozygosity. In contrast, minor alleles homozygosity of rs10741657 and rs1562902 in <jats:italic>CYP2R1<\/jats:italic> was associated with higher serum 25(OH)D concentrations compared with major alleles homozygosity (all <jats:italic>P<\/jats:italic>&lt;0\u00b7001). Interestingly, the association between season and serum 25(OH)D concentrations was modified by <jats:italic>GC<\/jats:italic> rs7041 (<jats:italic>P<\/jats:italic><jats:sub>interaction<\/jats:sub>=0\u00b7044), observed as absence of increase in serum 25(OH)D from winter to spring among children with minor alleles homozygous genotypes compared with the two other genotypes of rs7041 (<jats:italic>P<\/jats:italic>&lt;0\u00b7001). Our results suggest that common genetic variants are associated with lower serum 25(OH)D concentrations across a school year. Potentially due to modified serum 25(OH)D response to UVB sunlight exposure. Further confirmation and paediatric studies investigating vitamin D-related health outcomes of these genotypic differences are needed.<\/jats:p>","DOI":"10.1017\/s0007114517000538","type":"journal-article","created":{"date-parts":[[2017,4,6]],"date-time":"2017-04-06T05:22:29Z","timestamp":1491456149000},"page":"829-838","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":28,"title":["Common genetic variants are associated with lower serum 25-hydroxyvitamin D concentrations across the year among children at northern latitudes"],"prefix":"10.1017","volume":"117","author":[{"given":"Rikke A.","family":"Petersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesli H.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla T.","family":"Damsgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise B.","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads F.","family":"Hjorth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inge","family":"Tetens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Krarup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-8996","authenticated-orcid":false,"given":"Arne","family":"Astrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim F.","family":"Michaelsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"M\u00f8lgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"S0007114517000538_ref25","unstructured":"Statistics Denmark (2011) Immigrants and their descendants. https:\/\/www.dst.dk\/da\/Statistik\/emner\/indvandrere-og-efterkommere\/indvandrere-og-efterkommere?tab=dok (accessed February 2012)."},{"key":"S0007114517000538_ref44","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-2704"},{"key":"S0007114517000538_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60588-0"},{"key":"S0007114517000538_ref49","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2829"},{"key":"S0007114517000538_ref23","doi-asserted-by":"publisher","DOI":"10.1177\/1403494812463173"},{"key":"S0007114517000538_ref42","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7244.1240"},{"key":"S0007114517000538_ref31","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2005801"},{"key":"S0007114517000538_ref1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.81.1.10"},{"key":"S0007114517000538_ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087292"},{"key":"S0007114517000538_ref12","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.059469"},{"key":"S0007114517000538_ref29","doi-asserted-by":"publisher","DOI":"10.3402\/fnr.v57i0.21434"},{"key":"S0007114517000538_ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515003372"},{"key":"S0007114517000538_ref33","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-808"},{"key":"S0007114517000538_ref45","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1306357"},{"key":"S0007114517000538_ref46","first-page":"27","article-title":"Large individual differences in serum 25-hydroxyvitamin D response to vitamin D supplementation: effects of genetic factors, body mass index, and baseline concentration. 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