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In this 12-week open-label, parallel-arm randomised controlled trial, 122 overweight\/obese men and women were administered either a HPMR or a control diet after 2 weeks of diet and exercise run-in. Body weight, waist circumference (WC), percentage body fat (%BF), fasting blood glucose, post-oral glucose tolerance test (post-OGTT) blood glucose, fasting and post-OGTT serum insulin, lipid profile, high-sensitivity C-reactive protein (hs-CRP), kidney function and hepatic aminotransferases were assessed before and after the intervention. Additional improvement in mean values for the following parameters in the HPMR group compared with the control group was observed: body weight, 4\u00b79 % (95 % CI 3\u00b78, 6\u00b71; <jats:italic>P<\/jats:italic>&lt;0\u00b7001); WC, 3\u00b78 % (95 % CI 2\u00b75, 5\u00b71; <jats:italic>P<\/jats:italic>&lt;0\u00b7001); %BF, 6\u00b73 % (95 % CI 4\u00b73, 8\u00b72; <jats:italic>P<\/jats:italic>&lt;0\u00b7001); systolic blood pressure, 2\u00b78 % (95 % CI 0\u00b74, 5\u00b71; <jats:italic>P<\/jats:italic>=0\u00b7002); diastolic blood pressure, 3\u00b75 % (95 % CI 0\u00b77, 6\u00b73; <jats:italic>P<\/jats:italic>= 0\u00b701); post-OGTT blood glucose, 7\u00b73 % (95 % CI 1\u00b74, 13\u00b71; <jats:italic>P<\/jats:italic>=0\u00b702); total cholesterol, 2\u00b75 % (95 % CI 1\u00b76, 3\u00b75; <jats:italic>P<\/jats:italic>&lt;0\u00b7001); LDL-cholesterol, 7\u00b73 % (95 % CI 1\u00b77, 12\u00b79; <jats:italic>P<\/jats:italic>&lt;0\u00b701); alanine aminotransferase, 22\u00b70 % (95 % CI 2\u00b71, 42; <jats:italic>P<\/jats:italic>=0\u00b703) and aspartate aminotransferase, 15\u00b72 % (95 % CI 0\u00b79, 29\u00b75; <jats:italic>P<\/jats:italic>=0\u00b704). The absolute reduction in BMI was 0\u00b79 units in the intervention arm compared with the control arm (\u20130\u00b79 %, 95 % CI \u20131\u00b74, \u20130\u00b75; <jats:italic>P<\/jats:italic>&lt;0\u00b7001) and in serum TAG was 11\u00b79 mg\/dl (\u201311\u00b79 mg\/dl, 95 % CI \u201321\u00b71, \u20132\u00b77; <jats:italic>P<\/jats:italic>&lt;0\u00b701). The reduction in fasting serum insulin in the intervention <jats:italic>v.<\/jats:italic> the control arm was 3\u00b78 <jats:italic>v.<\/jats:italic> 0 % (<jats:italic>P<\/jats:italic>=0\u00b7002); post-OGTT serum insulin was 50\u00b73 <jats:italic>v.<\/jats:italic> 77\u00b73 mU\/l (<jats:italic>P<\/jats:italic>=0\u00b7005); and hs-CRP, 16\u00b77 % <jats:italic>v.<\/jats:italic> 0 % (<jats:italic>P<\/jats:italic>=0\u00b7002). These findings show that intervention with HPMR may lead to significant weight loss and improvement in obesity measures, metabolic, lipid and inflammatory parameters and hepatic transaminases in overweight\/obese Asian Indians.<\/jats:p>","DOI":"10.1017\/s0007114517001295","type":"journal-article","created":{"date-parts":[[2017,6,27]],"date-time":"2017-06-27T05:45:07Z","timestamp":1498542307000},"page":"1531-1540","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":49,"title":["Effect of high-protein meal replacement on weight and cardiometabolic profile in overweight\/obese Asian Indians in North 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