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At first exogenous feeding, fry were fed either a marine-based diet (Diet M<jats:sup>stimulus<\/jats:sup>, 80% fishmeal (FM)\/4% fish oil (FO)) or a vegetable-based diet (Diet V<jats:sup>stimulus<\/jats:sup>, 10% FM\/0% FO) for 3 weeks. Subsequently, all fish were then fed under the same conditions with a commercial, marine-based, diet for 15 weeks and thereafter challenged with a second V diet (Diet V<jats:sup>challenge<\/jats:sup>, 10% FM\/0% FO) for 6 weeks. Diploid and triploid siblings were run in parallel to examine ploidy effects. Growth performance, feed intake, nutrient utilisation and intestinal morphology were monitored. Fish initially given Diet V<jats:sup>stimulus<\/jats:sup>(V-fish) showed 24 % higher growth rate and 23 % better feed efficiency compared with M-fish when later challenged with Diet V<jats:sup>challenge<\/jats:sup>. There was no difference in feed intake between nutritional histories, but increased nutrient retentions highlighted the improved utilisation of a V diet in V-fish. There were generally few significant effects of nutritional history or ploidy on enteritis scores in the distal intestine after the challenge phase as only V-triploids showed a significant increase (<jats:italic>P<\/jats:italic>&lt;0\u00b705) in total score. The data highlighted that the positive effects were most likely a result of nutritional programming and the ability to respond better when challenged later in life may be attributed to physiological and\/or metabolic changes induced by the stimulus. This novel study showed the potential of nutritional programming to improve the use of plant raw material ingredients in feeds for Atlantic salmon.<\/jats:p>","DOI":"10.1017\/s0007114517001842","type":"journal-article","created":{"date-parts":[[2017,7,24]],"date-time":"2017-07-24T06:23:47Z","timestamp":1500877427000},"page":"17-29","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":62,"title":["Early nutritional intervention can improve utilisation of vegetable-based diets in diploid and triploid Atlantic salmon (<i>Salmo salar<\/i>L.)"],"prefix":"10.1017","volume":"118","author":[{"given":"Michael","family":"Clarkson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herve","family":"Migaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoforos","family":"Metochis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa M.","family":"Vera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Leeming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas R.","family":"Tocher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John 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