{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T22:08:58Z","timestamp":1792534138730,"version":"4.5.0"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T00:00:00Z","timestamp":1503014400000},"content-version":"unspecified","delay-in-days":21,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2017,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The inhibition by 1,5-anhydro-<jats:sc>d<\/jats:sc>-glucitol (1,5-AG) was determined on disaccharidases of rats and humans. Then, the metabolism and fate of 1,5-AG was investigated in rats and humans. Although 1,5-AG inhibited about 50 % of sucrase activity in rat small intestine, the inhibition was less than half of <jats:sc>d<\/jats:sc>-sorbose. 1,5-AG strongly inhibited trehalase and lactase, whereas <jats:sc>d<\/jats:sc>-sorbose inhibited them very weakly. 1,5-AG noncompetitively inhibited sucrase. The inhibition of 1,5-AG on sucrase and maltase was similar between humans and rats. 1,5-AG in serum increased 30 min after oral administration of 1,5-AG (600 mg) in rats, and mostly 100 % of 1,5-AG was excreted into the urine 24 h after administration. 1,5-AG in serum showed a peak 30 min after ingestion of 1,5-AG (20 g) by healthy subjects, and decreased gradually over 180 min. About 60 % of 1,5-AG was excreted into the urine for 9 h following ingestion. Hydrogen was scarcely excreted in both rats and humans 24 h after administration of 1,5-AG. Furthermore, 1,5-AG significantly suppressed the blood glucose elevation, and hydrogen excretion was increased following the simultaneous ingestion of sucrose and 1,5-AG in healthy subjects. 1,5-AG also significantly suppressed the blood glucose elevation following the simultaneous ingestion of glucose and 1,5-AG; however, hydrogen excretion was negligible. The available energy of 1,5-AG, which is absorbed readily from the small intestine and excreted quickly into the urine, is 0 kJ\/g (0 kcal\/g). Furthermore, 1,5-AG might suppress the blood glucose elevation through the inhibition of sucrase, as well as intestinal glucose absorption.<\/jats:p>","DOI":"10.1017\/s0007114517001866","type":"journal-article","created":{"date-parts":[[2017,8,18]],"date-time":"2017-08-18T11:14:10Z","timestamp":1503054850000},"page":"81-91","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":21,"title":["Effects of 1,5-anhydroglucitol on postprandial blood glucose and insulin levels and hydrogen excretion in rats and healthy humans"],"prefix":"10.1017","volume":"118","author":[{"given":"Sadako","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Tanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Yoshinaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumio","family":"Shimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuneyuki","family":"Oku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2017,8,18]]},"reference":[{"key":"S0007114517001866_ref19","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1093\/jn\/114.9.1574","article-title":"Nondigestibility of a new sweetener \u2018Neosugar\u2019 in the rat","volume":"114","author":"Oku","year":"1984","journal-title":"J Nutr"},{"key":"S0007114517001866_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/BF00277486"},{"key":"S0007114517001866_ref5","unstructured":"Japan Food Research Laboratories (2005) Report of mutagenicity test on 1, 5-anhydroglucitol, no. 405110167-001. 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