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The objective of this study was to determine the effectiveness of daily antenatal supplementation with multiple micronutrients (MMN) compared with folic acid (FA) on the occurrence of anaemia among pregnant women and their infants\u2019 health in a high-altitude area. A prospective cohort study was carried out in two rural counties in Tibet from 2007 to 2012. A total of 1149 eligible pregnant women were allocated daily supplementation with FA in one county and MMN containing a recommended allowance of twenty-three vitamins and minerals in another county starting \u226424 weeks of gestation and continuing until delivery. Compared with the FA group, prenatal supplementation with MMN was significantly associated with reduced odds of anaemia in the third trimester. This was demonstrated in the primary outcome, with an adjusted OR (AOR) of 0\u00b763; 95 % CI 0\u00b745, 0\u00b788 and <jats:italic>P<\/jats:italic>=0\u00b7007 and also reduced odds of preterm delivery (AOR: 0\u00b731; 95 % CI 0\u00b715, 0\u00b761; <jats:italic>P<\/jats:italic>=0\u00b7001). There was no difference between MMN and FA groups in mean birth weight (adjusted mean difference: 36\u00b778; 95 % CI \u221219\u00b742, 92\u00b798 g; <jats:italic>P<\/jats:italic>=0\u00b7200), whereas MMN supplementation significantly reduced the odds of low-birth weight (LBW) babies (AOR: 0\u00b758; 95 % CI 0\u00b736, 0\u00b791; <jats:italic>P<\/jats:italic>=0\u00b7019). In conclusion, the antenatal MMN supplementation in rural Tibet is associated with a reduction of maternal anaemia in the third trimester, and may potentially decrease the risk of preterm delivery and LBW babies.<\/jats:p>","DOI":"10.1017\/s000711451700229x","type":"journal-article","created":{"date-parts":[[2017,10,5]],"date-time":"2017-10-05T14:03:30Z","timestamp":1507212210000},"page":"431-440","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":20,"title":["Multi-micronutrient supplementation during pregnancy for prevention of maternal anaemia and adverse birth outcomes in a high-altitude area: a prospective cohort study in rural Tibet of China"],"prefix":"10.1017","volume":"118","author":[{"given":"Yijun","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaonong","family":"Dang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingxia","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duolao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luobu","family":"Ouzhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,10,5]]},"reference":[{"key":"S000711451700229X_ref3","unstructured":"National Health and Family Planning Commission of the PRC (NHFPC) (2015) Report of nutrition and chronic disease status of Chinese residents. http:\/\/www.nhfpc.gov.cn\/jkj\/s5879\/201506\/4505528e65f3460fb88685081ff158a2.shtml (accessed June 2016)."},{"key":"S000711451700229X_ref26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f3443"},{"key":"S000711451700229X_ref30","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6978.489"},{"key":"S000711451700229X_ref7","first-page":"668","article-title":"[Levels of hemoglobin concentration and anemia during pregnancy in Lhasa]","volume":"29","author":"Xing","year":"2008","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"S000711451700229X_ref42","doi-asserted-by":"publisher","DOI":"10.1024\/1661-8157.96.34.1241"},{"key":"S000711451700229X_ref36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2012.01291.x"},{"key":"S000711451700229X_ref39","doi-asserted-by":"publisher","DOI":"10.3945\/jn.114.208678"},{"key":"S000711451700229X_ref40","doi-asserted-by":"crossref","first-page":"1218S","DOI":"10.1093\/ajcn\/81.5.1218","article-title":"Iron status during pregnancy: setting the stage for mother and infant","volume":"81","author":"Scholl","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"S000711451700229X_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70001-9"},{"key":"S000711451700229X_ref27","unstructured":"Maternal and Child Health Division (2010) Project management plan on folic acid supplementation prevented neural tube defects. 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