{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:16:05Z","timestamp":1781079365811,"version":"3.54.1"},"reference-count":52,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T00:00:00Z","timestamp":1507680000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2017,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The<jats:italic>in vivo<\/jats:italic>effects of administering free and microencapsulated<jats:italic>Lactobacillus plantarum<\/jats:italic>LIP-1 cells (2\u00b70\u00d710<jats:sup>9<\/jats:sup>colony-forming units\/d) were evaluated in high-fat-diet-induced hyperlipidaemic rats. Results from real-time quantitative PCR targeting to LIP-1 cells showed a higher colon colonisation count of LIP-1 in the rats receiving microencapsulated cells compared with free cells (<jats:italic>P<\/jats:italic>&lt;0\u00b705). Moreover, the microencapsulated LIP-1 treatment resulted in a more obvious lipid-lowering effect (<jats:italic>P<\/jats:italic>&lt;0\u00b705). Meanwhile, their faecal samples had significantly less lipopolysaccharide-producing bacteria (especially<jats:italic>Bilophila<\/jats:italic>,<jats:italic>Sutterella<\/jats:italic>and<jats:italic>Oscillibacter<\/jats:italic>) and mucosa-damaging bacteria (<jats:italic>Bilophila<\/jats:italic>and<jats:italic>Akkermansia muciniphila<\/jats:italic>), whereas significantly more SCFA-producing bacteria (<jats:italic>P<\/jats:italic>&lt;0\u00b705) (namely<jats:italic>Lactobacillus<\/jats:italic>,<jats:italic>Alloprevotella<\/jats:italic>,<jats:italic>Coprococcus<\/jats:italic>,<jats:italic>Eubacterium<\/jats:italic>and<jats:italic>Ruminococcus<\/jats:italic>) and bacteria that potentially possessed bile salt hydrolase activity (<jats:italic>Bacteroides<\/jats:italic>,<jats:italic>Clostridium<\/jats:italic>,<jats:italic>Eubacterium<\/jats:italic>and<jats:italic>Lactobacillus<\/jats:italic>), and other beneficial bacteria (<jats:italic>Alistipes<\/jats:italic>and<jats:italic>Turicibacter<\/jats:italic>). Further, Spearman\u2019s correlation analysis showed significant correlations between some of the modulated gut bacteria and the serum lipid levels. These results together confirm that microcapsulation enhanced the colon colonisation of LIP-1 cells, which subsequently exhibited more pronounced effects in improving the gut microbiota composition of hyperlipidaemic rats and lipid reduction.<\/jats:p>","DOI":"10.1017\/s0007114517002380","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T08:55:06Z","timestamp":1507712106000},"page":"481-492","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":95,"title":["Effects of microencapsulated<i>Lactobacillus plantarum<\/i>LIP-1 on the gut microbiota of hyperlipidaemic rats"],"prefix":"10.1017","volume":"118","author":[{"given":"Jiao J.","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen 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