{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:31:03Z","timestamp":1790285463520,"version":"4.1.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T00:00:00Z","timestamp":1519948800000},"content-version":"unspecified","delay-in-days":2,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2018,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Strenuous physical exercise and hyperthermia may paradoxically induce oxidative stress and adverse effects on myocardial function. The purpose of this study was to investigate the effect of 14-d coenzyme Q<jats:sub>10<\/jats:sub>(CoQ<jats:sub>10<\/jats:sub>) supplementation and pre-cooling on serum creatine kinase-MB (CK-MB), cardiac Troponin I (cTnI), myoglobin (Mb), lactate dehydrogenase (LD), total antioxidant capacity (TAC), lipid peroxidation (LPO) and CoQ<jats:sub>10<\/jats:sub>concentration in elite swimmers. In total, thirty-six healthy males (mean age 17 (<jats:sc>sd<\/jats:sc>1) years) were randomly selected and divided into four groups of supplementation, supplementation with pre-cooling, pre-cooling and control. During an eighteen-session protocol in the morning and evening, subjects attended speed and endurance swimming training sessions for 5 km in each session. Blood sampling was done before (two stages) and after (two stages) administration of CoQ<jats:sub>10<\/jats:sub>and pre-cooling. ANCOVA and repeated measurement tests with Bonferroni<jats:italic>post hoc<\/jats:italic>test were used for the statistical analysis of the data. There was no significant statistical difference among groups for the levels of CK-MB, cTnI, Mb, LD, TAC, LPO and CoQ<jats:sub>10<\/jats:sub>at the presampling (stages 1 and 2) (<jats:italic>P<\/jats:italic>&gt;0\u00b705). However, pre-cooling and control groups show a significant increase in the levels of CK-MB, cTnI, Mb, LD and LPO compared with the supplementation and supplementation with pre-cooling groups in the post-sampling (stages 1 and 2) (<jats:italic>P<\/jats:italic>&lt;0\u00b705), except for the TAC and CoQ<jats:sub>10<\/jats:sub>. Consequently, CoQ<jats:sub>10<\/jats:sub>supplementation prevents adverse changes of myocardial damage and oxidative stress during swimming competition phase. Meanwhile, the pre-cooling strategy individually has no desired effect on the levels of CK-MB, cTnI, Mb, LD, LPO, TAC and CoQ<jats:sub>10<\/jats:sub>.<\/jats:p>","DOI":"10.1017\/s0007114517003774","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T11:38:53Z","timestamp":1519990733000},"page":"381-390","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":25,"title":["The effect of short-term coenzyme Q<sub>10<\/sub>supplementation and pre-cooling strategy on cardiac damage markers in elite swimmers"],"prefix":"10.1017","volume":"119","author":[{"given":"Ali","family":"Emami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghar","family":"Tofighi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siamak","family":"Asri-Rezaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnaz","family":"Bazargani-Gilani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2018,3,2]]},"reference":[{"key":"S0007114517003774_ref20","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2012-091739"},{"key":"S0007114517003774_ref18","doi-asserted-by":"publisher","DOI":"10.2174\/1874387001004010001"},{"key":"S0007114517003774_ref28","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000210192.49210.fc"},{"key":"S0007114517003774_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.mito.2007.02.012"},{"key":"S0007114517003774_ref10","doi-asserted-by":"publisher","DOI":"10.1080\/02640410801974992"},{"key":"S0007114517003774_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh148"},{"key":"S0007114517003774_ref8","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000131958.18154.1E"},{"key":"S0007114517003774_ref6","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/761264"},{"key":"S0007114517003774_ref33","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/465020"},{"key":"S0007114517003774_ref4","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-10-166"},{"key":"S0007114517003774_ref2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2001.280.2.H509"},{"key":"S0007114517003774_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(01)00406-5"},{"key":"S0007114517003774_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2013-092928"},{"key":"S0007114517003774_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s004210100410"},{"key":"S0007114517003774_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2011.07.010"},{"key":"S0007114517003774_ref13","doi-asserted-by":"publisher","DOI":"10.17221\/1122-CJFS"},{"key":"S0007114517003774_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-011-0257-5"},{"key":"S0007114517003774_ref35","first-page":"305","article-title":"Oxidative stress and antioxidant defense in plasma after repeated bouts of supramaximal exercise: the effect of coenzyme Q10","volume":"51","author":"Gul","year":"2011","journal-title":"J Sports Med Phys Fitness"},{"key":"S0007114517003774_ref31","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508926544"},{"key":"S0007114517003774_ref14","doi-asserted-by":"publisher","DOI":"10.3758\/BRM.41.4.1149"},{"key":"S0007114517003774_ref25","doi-asserted-by":"crossref","unstructured":"Graves S , Sikorska M , Borowy-Borowski H , et al. 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