{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T02:39:23Z","timestamp":1794278363608,"version":"4.9.0"},"reference-count":42,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T00:00:00Z","timestamp":1526342400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["www.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2018,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to derive dietary patterns associated with cardio-metabolic traits and to examine whether these predict prospective changes in these traits and incidence of the metabolic syndrome (iMetS). Subjects from the Malm\u00f6 Diet and Cancer Study cardiovascular cohort without cardio-metabolic disease and related drug treatments at baseline (<jats:italic>n<\/jats:italic> 4071; aged 45\u201367 years, 40 % men) were included. We applied reduced rank regression on thirty-eight foods to derive patterns that explain variation in response variables measured at baseline (waist circumference, TAG, HDL- and LDL-cholesterol, systolic and diastolic blood pressure, fasting glucose and insulin). Patterns were examined in relation to change in cardio-metabolic traits and iMetS in subjects who were re-examined after 16\u00b77 years (<jats:italic>n<\/jats:italic> 2704). Two dietary patterns (\u2018Western\u2019 and \u2018Drinker\u2019) were retained and explained 3\u00b72 % of the variation in response variables. The \u2018Western\u2019 dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up. After adjustment for potential confounders, the \u2018Western\u2019 dietary pattern was associated with higher risk of iMetS (hazard ratio Q4 <jats:italic>v.<\/jats:italic> Q1: 1\u00b747; 95 % CI 1\u00b723, 1\u00b777; <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>=1\u00b75\u00d710<jats:sup>\u22125<\/jats:sup>). The \u2018Drinker\u2019 dietary pattern primarily explained variation in HDL and was not associated with iMetS. In conclusion, this study supports current food-based dietary guidelines suggesting that a \u2018Western\u2019 dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables and high-fibre foods is associated with detrimental effects on cardio-metabolic health.<\/jats:p>","DOI":"10.1017\/s000711451800079x","type":"journal-article","created":{"date-parts":[[2018,5,15]],"date-time":"2018-05-15T08:29:26Z","timestamp":1526372966000},"page":"1168-1176","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":122,"title":["A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic 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