{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T05:35:03Z","timestamp":1771911303352,"version":"3.50.1"},"reference-count":48,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T00:00:00Z","timestamp":1540512000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2019,1,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The polyphenolic extract (PE) from extra virgin olive oil (EVOO) has been shown to possess important anti-inflammatory and joint protective properties in murine models of rheumatoid arthritis (RA). This study was designed to evaluate the effects of PE on IL-1<jats:italic>\u03b2<\/jats:italic>-activated human synovial fibroblasts SW982 cell line. PE from EVOO treatment inhibited IL-1<jats:italic>\u03b2<\/jats:italic>-induced matrix metalloproteases (<jats:italic>P<\/jats:italic>&lt;0\u00b7001), TNF-<jats:italic>\u03b1<\/jats:italic>and IL-6 production (<jats:italic>P<\/jats:italic>&lt;0\u00b7001). Similarly, IL-1<jats:italic>\u03b2<\/jats:italic>-induced cyclo-oxygenase-2 and microsomal PGE synthase-1 up-regulations were down-regulated by PE (<jats:italic>P<\/jats:italic>&lt;0\u00b7001). Moreover, IL-1<jats:italic>\u03b2<\/jats:italic>-induced mitogen-activated protein kinase (MAPK) phosphorylation and NF-<jats:italic>\u03ba<\/jats:italic>B activation were ameliorated by PE (<jats:italic>P<\/jats:italic>&lt;0\u00b7001). These results suggest that PE from EVOO reduces the production of proinflammatory mediators in human synovial fibroblasts; particularly, these protective effects could be related to the inhibition of MAPK and NF-<jats:italic>\u03ba<\/jats:italic>B signalling pathways. Taken together, PE from EVOO probably could provide an attractive complement in management of diseases associated with over-activation of synovial fibroblasts, such as RA.<\/jats:p>","DOI":"10.1017\/s0007114518002829","type":"journal-article","created":{"date-parts":[[2018,10,26]],"date-time":"2018-10-26T05:36:56Z","timestamp":1540532216000},"page":"55-62","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":33,"title":["Polyphenolic extract from extra virgin olive oil inhibits the inflammatory response in IL-1<i>\u03b2<\/i>-activated synovial fibroblasts"],"prefix":"10.1017","volume":"121","author":[{"given":"Mar\u00eda \u00c1ngeles","family":"Rosillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catalina","family":"Alarc\u00f3n-de-la-Lastra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Luisa","family":"Castej\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Cejudo-Guill\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"S\u00e1nchez-Hidalgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,10,26]]},"reference":[{"key":"S0007114518002829_ref15","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.182808"},{"key":"S0007114518002829_ref11","doi-asserted-by":"publisher","DOI":"10.2174\/1381612013397654"},{"key":"S0007114518002829_ref7","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215528"},{"key":"S0007114518002829_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00626.x"},{"key":"S0007114518002829_ref18","doi-asserted-by":"publisher","DOI":"10.1021\/jf3032765"},{"key":"S0007114518002829_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kel065"},{"key":"S0007114518002829_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2008.11.048"},{"key":"S0007114518002829_ref38","doi-asserted-by":"publisher","DOI":"10.3109\/08916939808995367"},{"key":"S0007114518002829_ref12","doi-asserted-by":"publisher","DOI":"10.2174\/09298673113209990159"},{"key":"S0007114518002829_ref6","doi-asserted-by":"publisher","DOI":"10.1186\/ar113"},{"key":"S0007114518002829_ref31","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2001.2614"},{"key":"S0007114518002829_ref10","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO01094F"},{"key":"S0007114518002829_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780391103"},{"key":"S0007114518002829_ref14","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-015-0850-0"},{"key":"S0007114518002829_ref48","doi-asserted-by":"publisher","DOI":"10.1016\/S1570-0232(02)00855-3"},{"key":"S0007114518002829_ref27","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.126532"},{"key":"S0007114518002829_ref41","doi-asserted-by":"publisher","DOI":"10.1039\/C4FO00014E"},{"key":"S0007114518002829_ref20","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.13.1107"},{"key":"S0007114518002829_ref30","first-page":"89","article-title":"Concentrations of prostaglandins D2, E2, F2 alpha, 6-keto-F1 alpha and thromboxane B2 in synovial fluid from patients with inflammatory joint disorders and osteoarthritis","volume":"43","author":"Egg","year":"1984","journal-title":"Z Rheumatol"},{"key":"S0007114518002829_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"S0007114518002829_ref37","doi-asserted-by":"publisher","DOI":"10.1186\/ar300"},{"key":"S0007114518002829_ref9","doi-asserted-by":"publisher","DOI":"10.1039\/C6FO00485G"},{"key":"S0007114518002829_ref16","first-page":"185","article-title":"Componentes fenolicos de la aceituna. III Polifenoles del aceite","volume":"27","author":"V\u00e1zquez-Roncero","year":"1976","journal-title":"Grasas Aceites"},{"key":"S0007114518002829_ref17","doi-asserted-by":"publisher","DOI":"10.1021\/jf070628u"},{"key":"S0007114518002829_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/art.20615"},{"key":"S0007114518002829_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2012.190"},{"key":"S0007114518002829_ref2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-136-12-200206180-00012"},{"key":"S0007114518002829_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2014.07.006"},{"key":"S0007114518002829_ref24","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2001.37.7.844190"},{"key":"S0007114518002829_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.03.024"},{"key":"S0007114518002829_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22513"},{"key":"S0007114518002829_ref26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083555"},{"key":"S0007114518002829_ref29","first-page":"894","article-title":"Age at onset of rheumatoid arthritis: association with polymorphisms in the vascular endothelial growth factor A (VEGFA) gene and an intergenic locus between matrix metalloproteinase (MMP) 1 and 3 genes","volume":"30","author":"Chen","year":"2012","journal-title":"Clin Exp Rheumatol"},{"key":"S0007114518002829_ref32","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0245-7"},{"key":"S0007114518002829_ref33","doi-asserted-by":"publisher","DOI":"10.1172\/JCI12466"},{"key":"S0007114518002829_ref34","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200108)44:8<1897::AID-ART328>3.0.CO;2-4"},{"key":"S0007114518002829_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2004.03.004"},{"key":"S0007114518002829_ref36","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.2000.0743"},{"key":"S0007114518002829_ref39","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11830"},{"key":"S0007114518002829_ref40","doi-asserted-by":"publisher","DOI":"10.1039\/C7FO00210F"},{"key":"S0007114518002829_ref42","doi-asserted-by":"publisher","DOI":"10.1002\/art.27437"},{"key":"S0007114518002829_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.09.012"},{"key":"S0007114518002829_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.06.041"},{"key":"S0007114518002829_ref45","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201500304"},{"key":"S0007114518002829_ref46","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.3.409"},{"key":"S0007114518002829_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2010.07.004"},{"key":"S0007114518002829_ref47","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1179\/1351000215Y.0000000039","article-title":"The olive leaf extract oleuropein exerts protective effects against oxidant-induced cell death, concurrently displaying pro-oxidant activity in human hepatocarcinoma cells","volume":"21","author":"Katsoulieris","year":"2016","journal-title":"Redox Rep"},{"key":"S0007114518002829_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70206-4"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114518002829","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T02:55:27Z","timestamp":1605322527000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114518002829\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,26]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,14]]}},"alternative-id":["S0007114518002829"],"URL":"https:\/\/doi.org\/10.1017\/s0007114518002829","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,26]]},"assertion":[{"value":"\u00a9 The Authors 2018\u00a0","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}