{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:51:17Z","timestamp":1778709077713,"version":"3.51.4"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T00:00:00Z","timestamp":1572825600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2019,12,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pathogenesis of congenital diaphragmatic hernia (CDH) is largely unknown; however, vitamin A seems to play a role in diaphragmatic development. Previous case\u2013control studies reported that maternal dietary vitamin A intake was inversely associated with the risk of CDH. To our knowledge, however, there is no prospective evidence regarding this association. Our aim was to examine whether maternal intake of vitamin A was associated with CDH occurrence. Baseline data, from the Japan nationwide birth cohort study (2011\u20132014) of 89 658 mothers (mean age at delivery = 31\u00b72 years) who delivered singleton live births, were analysed. We assessed dietary habits using an FFQ focused on the first trimester and estimated the daily intake of total vitamin A (retinol activity equivalents), retinol, provitamin A carotenoids and vegetables. The occurrence of CDH was ascertained from medical records. A total of forty cases of CDH were documented. The adjusted OR of CDH occurrence for the high total vitamin A intake category (median = 468 \u03bcg\/d) was 0\u00b76 (95 % CI 0\u00b73, 1\u00b72) with reference to the low intake category (230 \u03bcg\/d). When we restricted to mothers with a prepregnancy BMI of 18\u00b75\u201324\u00b79 kg\/m<jats:sup>2<\/jats:sup>, vitamin A intake was inversely associated with the risk of their children being born with CDH (OR 0\u00b75, 95 % CI 0\u00b72, 1\u00b70). Even given the limited number of cases in the study, our findings provide additional evidence to link vitamin A with CDH.<\/jats:p>","DOI":"10.1017\/s0007114519002204","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T07:10:11Z","timestamp":1567408211000},"page":"1295-1302","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":18,"title":["Maternal dietary intake of vitamin A during pregnancy was inversely associated with congenital diaphragmatic hernia: the Japan Environment and Children\u2019s Study"],"prefix":"10.1017","volume":"122","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2298-5133","authenticated-orcid":false,"given":"Takehiro","family":"Michikawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makiko","family":"Sekiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji F.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yayoi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyuki","family":"Iwai-Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiko","family":"Suda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the Japan Environment and Children\u2019s Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,11,4]]},"reference":[{"key":"S0007114519002204_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23093"},{"key":"S0007114519002204_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(90)90190-K"},{"key":"S0007114519002204_ref8","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.060445"},{"key":"S0007114519002204_ref34","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0521"},{"key":"S0007114519002204_ref19","unstructured":"19. Ministry of Health, Labour and Welfare, Japan (2014) The National Health and Nutrition Survey in Japan, 2013. http:\/\/www.mhlw.go.jp\/bunya\/kenkou\/eiyou\/h25-houkoku.html (accessed April 2019)."},{"key":"S0007114519002204_ref7","first-page":"163","article-title":"Effect of diet during pregnancy upon the incidence of congenital hereditary diaphragmatic hernia in the rat; failure to produce cystic fibrosis of the pancreas by maternal vitamin A deficiency","volume":"25","author":"Andersen","year":"1949","journal-title":"Am J Pathol"},{"key":"S0007114519002204_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-008-2257-y"},{"key":"S0007114519002204_ref36","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.656"},{"key":"S0007114519002204_ref35","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23039"},{"key":"S0007114519002204_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.09.017"},{"key":"S0007114519002204_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2009.05.005"},{"key":"S0007114519002204_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114518002842"},{"key":"S0007114519002204_ref22","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20180014"},{"key":"S0007114519002204_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-14-25"},{"key":"S0007114519002204_ref23","volume-title":"Birth Defects Surveillance: A Manual for Programme Managers.","year":"2014"},{"key":"S0007114519002204_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2011.05.003"},{"key":"S0007114519002204_ref26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/bdra.20620","article-title":"Maternal obesity and morbid obesity: the risk for birth defects in the offspring","volume":"88","author":"Blomberg","year":"2010","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"S0007114519002204_ref30","doi-asserted-by":"publisher","DOI":"10.1079\/PHN2004635"},{"key":"S0007114519002204_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63861-8"},{"key":"S0007114519002204_ref28","unstructured":"28. The International Centre on Birth Defects (2014) International Clearinghouse Centre for Birth Defects surveillance and research annual report 2014. http:\/\/www.icbdsr.org\/resources\/annual-report\/ (accessed April 2019)."},{"key":"S0007114519002204_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451800291X"},{"key":"S0007114519002204_ref17","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20150064"},{"key":"S0007114519002204_ref14","doi-asserted-by":"publisher","DOI":"10.2188\/jea.JE20170018"},{"key":"S0007114519002204_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2013.04.015"},{"key":"S0007114519002204_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.12.017"},{"key":"S0007114519002204_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.4.1220S"},{"key":"S0007114519002204_ref20","unstructured":"20. Report of the Subdivision on Resources the Council for Science and Technology Ministry of Education, Culture, Sports, Science and Technology, Japan. Standard Tables of Food Composition in Japan 2010. Official Gazette Cooperation of Japan (in Japanese)."},{"key":"S0007114519002204_ref32","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00403.2003"},{"key":"S0007114519002204_ref29","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2012.15"},{"key":"S0007114519002204_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20436"},{"key":"S0007114519002204_ref18","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2010.03.001"},{"key":"S0007114519002204_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20735"},{"key":"S0007114519002204_ref25","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2013.858691"},{"key":"S0007114519002204_ref31","unstructured":"31. Ministry of Health, Labour and Welfare, Japan (2015) Dietary reference intakes for Japanese, 2015. https:\/\/www.mhlw.go.jp\/stf\/shingi\/0000041824.html (accessed April 2019)."},{"key":"S0007114519002204_ref10","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1242\/dev.120.10.2749","article-title":"Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants","volume":"120","author":"Mendelsohn","year":"1994","journal-title":"Development"},{"key":"S0007114519002204_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.09.025"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114519002204","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T21:14:55Z","timestamp":1721682895000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114519002204\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,4]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,12,14]]}},"alternative-id":["S0007114519002204"],"URL":"https:\/\/doi.org\/10.1017\/s0007114519002204","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,4]]},"assertion":[{"value":"\u00a9 The Authors 2019\u00a0","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}