{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:25:27Z","timestamp":1778826327128,"version":"3.51.4"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T00:00:00Z","timestamp":1573171200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2020,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin D deficiency is now a recognised problem affecting multiple physiological functions. The aim of the present study was to evaluate the effect of a single dose of vitamin D<jats:sub>3<\/jats:sub> injection on the inflammatory, muscular damage, metabolic and cardiovascular responses to an acute bout of resistance exercise (RE) in vitamin D-deficient resistance-trained males. Blood samples from fourteen vitamin D-deficient resistance-trained males were obtained during two separate trials: lower vitamin D (LVD) and higher vitamin D (HVD, after vitamin D<jats:sub>3<\/jats:sub> injection). Metabolic, inflammatory, muscle damage and cardiovascular markers were evaluated at baseline, immediately and 1 h after RE. There were significant trial-by-time interactions for insulin and homeostatic model assessment of insulin resistance (HOMA-IR) which significantly (<jats:italic>P<\/jats:italic> &lt; 0\u00b705) declined for 1 h after RE in the HVD trial compared with the LVD trial. Homeostasis model assessment of <jats:italic>\u03b2<\/jats:italic>-cell function (HOMA-<jats:italic>\u03b2<\/jats:italic>) declines at 1 h post-RE in the HVD trial. There was also a time effect for blood sugar which significantly (<jats:italic>P &lt;<\/jats:italic> 0\u00b705) decreased and for creatine kinase, lactate dehydrogenase and IL-6 which increased significantly 1 h post-RE in both trials. There were no significant changes in other inflammatory and cardiovascular markers following both trials. A single injection of vitamin D<jats:sub>3<\/jats:sub> improved insulin resistance and <jats:italic>\u03b2<\/jats:italic>-cell function following RE in previously vitamin D-deficient resistance-trained males. Conversely, the injection did not change muscle damage and the inflammatory response to acute RE. Intramuscular vitamin D replacement may have key implications for the promotion of glucose metabolism and lowering the risk of diabetes in vitamin D-deficient individuals.<\/jats:p>","DOI":"10.1017\/s0007114519002770","type":"journal-article","created":{"date-parts":[[2019,11,8]],"date-time":"2019-11-08T11:46:22Z","timestamp":1573213582000},"page":"394-401","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["A single injection of vitamin D<sub>3<\/sub> improves insulin sensitivity and <i>\u03b2<\/i>-cell function but not muscle damage or the inflammatory and cardiovascular responses to an acute bout of resistance exercise in vitamin D-deficient resistance-trained 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