{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:25:16Z","timestamp":1791919516321,"version":"4.3.4"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2020,8,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here, we explored the influences of dietary inulin (INU) supplementation on growth performance and intestinal health in a porcine model. Thirty-two male weaned pigs (with an average body weight of 7\u00b710 (<jats:sc>sd<\/jats:sc> 0\u00b720) kg) were randomly assigned to four treatments and fed with a basal diet (BD) or BD containing 2\u00b75, 5\u00b70 and 10\u00b70 g\/kg INU. After a 21-d trial, pigs were killed for collection of serum and intestinal tissues. We show that INU supplementation had no significant influence on the growth performance in weaned pigs. INU significantly elevated serum insulin-like growth factor-1 concentration but decreased diamine oxidase concentration (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). Interestingly, 2\u00b75 and 5\u00b70 g\/kg INU supplementation significantly elevated the villus height in jejunum and ileum (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). Moreover, 2\u00b75 and 5\u00b70 g\/kg INU supplementation also elevated the villus height to crypt depth (V:C) in the duodenum and ileum and improved the distribution and abundance of tight-junction protein zonula occludens-1 in duodenum and ileum epithelium. INU supplementation at 10\u00b70 g\/kg significantly elevated the sucrase activity in the ileum mucosa (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). INU supplementation decreased the expression level of TNF-<jats:italic>\u03b1<\/jats:italic> but elevated the expression level of GLUT 2 and divalent metal transporter 1 in the intestinal mucosa (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). Moreover, INU increased acetic and butyric acid concentrations in caecum (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). Importantly, INU elevated the <jats:italic>Lactobacillus<\/jats:italic> population but decreased the <jats:italic>Escherichia coli<\/jats:italic> population in the caecum (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). These results not only indicate a beneficial effect of INU on growth performance and intestinal barrier functions but also offer potential mechanisms behind the dietary fibre-regulated intestinal health.<\/jats:p>","DOI":"10.1017\/s0007114520001130","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T06:15:55Z","timestamp":1585289755000},"page":"296-305","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":37,"title":["Effects of dietary inulin supplementation on growth performance, intestinal barrier integrity and microbial populations in weaned pigs"],"prefix":"10.1017","volume":"124","author":[{"given":"Weikang","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6605-6742","authenticated-orcid":false,"given":"Bing","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-9297","authenticated-orcid":false,"given":"Zhiqing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangbing","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuheng","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-9766","authenticated-orcid":false,"given":"Jun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"S0007114520001130_ref16","first-page":"210","volume-title":"Nutrient Requirements of Swine","year":"2012"},{"key":"S0007114520001130_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400021653"},{"key":"S0007114520001130_ref30","doi-asserted-by":"publisher","DOI":"10.1177\/014860718701100128"},{"key":"S0007114520001130_ref5","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.154625"},{"key":"S0007114520001130_ref41","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1093\/jn\/118.12.1482","article-title":"Availability of cereal fructans and inulin in the rat intestinal tract","volume":"118","author":"Urban","year":"1988","journal-title":"J Nutr"},{"key":"S0007114520001130_ref4","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00081.2009"},{"key":"S0007114520001130_ref28","doi-asserted-by":"publisher","DOI":"10.1177\/014860719902300522"},{"key":"S0007114520001130_ref42","doi-asserted-by":"publisher","DOI":"10.3382\/ps.0702433"},{"key":"S0007114520001130_ref21","doi-asserted-by":"publisher","DOI":"10.1093\/jas\/skz090"},{"key":"S0007114520001130_ref31","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005565708038"},{"key":"S0007114520001130_ref37","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.37.611"},{"key":"S0007114520001130_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquaculture.2009.04.025"},{"key":"S0007114520001130_ref39","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.3945\/jn.112.164947","article-title":"Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge","volume":"142","author":"Yulan","year":"2012","journal-title":"J Nutr"},{"key":"S0007114520001130_ref2","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2014.1000707"},{"key":"S0007114520001130_ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2653"},{"key":"S0007114520001130_ref15","doi-asserted-by":"publisher","DOI":"10.1080\/20014091091841"},{"key":"S0007114520001130_ref3","first-page":"3","article-title":"Nutrition and pathology of weaner pigs: nutritional strategies to support barrier function in the gastrointestinal tract","volume":"83","author":"Kim","year":"2001","journal-title":"Anim Feed Sci Tech"},{"key":"S0007114520001130_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.3.830S"},{"key":"S0007114520001130_ref7","unstructured":"7. 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