{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:53:12Z","timestamp":1787165592409,"version":"build-2736575974"},"reference-count":48,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T00:00:00Z","timestamp":1590710400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2020,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The occurrence of anorectal malformations (ARM) is thought to be reduced with sufficient folate intake. However, there is no apparent evidence. We focused on enzyme cofactors for one-carbon metabolism, including folate (vitamin B\n                    <jats:sub>9<\/jats:sub>\n                    ), vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    and vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    , and explored the association between maternal combined intake of these B vitamins and the risk of ARM. Using baseline data from a Japanese nationwide birth cohort study between 2011 and 2014, we analysed data of 89 235 women (mean age at delivery = 31\u00b72 years) who delivered singleton live births without chromosomal anomalies. Information on dietary intake was obtained via a FFQ focused on early pregnancy and used to estimate B vitamin intake. We also collected information on the frequency of folic acid supplement use. ARM occurrence was ascertained from medical records. We identified forty-three cases of ARM diagnosed up to the first month after birth (4\u00b78 per 10 000 live births). In terms of individual intake of the respective B vitamins, high vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    intake was non-significantly associated with reduced odds of ARM. Compared with women in the low combined B vitamin intake group, the OR of having an infant with ARM was 0\u00b74 (95 % CI 0\u00b72, 1\u00b70) in the high intake group (folate \u2265400 \u03bcg\/d, and upper half of vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    and\/or vitamin B\n                    <jats:sub>12<\/jats:sub>\n                    ). In conclusion, our cohort analysis suggested an inverse association between the combined intake of one-carbon metabolism-related B vitamins in early pregnancy and ARM occurrence.\n                  <\/jats:p>","DOI":"10.1017\/s0007114520001816","type":"journal-article","created":{"date-parts":[[2020,5,29]],"date-time":"2020-05-29T05:46:10Z","timestamp":1590731170000},"page":"865-873","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Maternal intake of one-carbon metabolism-related B vitamins and anorectal malformations in the Japan Environment and Children\u2019s Study"],"prefix":"10.1017","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2298-5133","authenticated-orcid":false,"given":"Takehiro","family":"Michikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Nitta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makiko","family":"Sekiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Kuroda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji F.","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayoi","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Iwai-Shimada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiko","family":"Suda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Japan Environment and Children\u2019s Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"S0007114520001816_ref33","doi-asserted-by":"publisher","DOI":"10.2188\/jea.15.29"},{"key":"S0007114520001816_ref47","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1494712"},{"key":"S0007114520001816_ref29","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.4934"},{"key":"S0007114520001816_ref30","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-25"},{"key":"S0007114520001816_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20210"},{"key":"S0007114520001816_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2019.03.004"},{"key":"S0007114520001816_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.11.1051"},{"key":"S0007114520001816_ref28","unstructured":"28. 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